Antihypercholesterolemic and antioxidant effect of sterol rich methanol extract of stem of Musa sapientum (banana) in cholesterol fed wistar rats

Piyush Dikshit, Mool Kumar Tyagi, Kirtikar Shukla, Jasvindar K. Gambhir, Rimi Shukla

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Musa sapientum Linn. (English ‘Banana’ family Musaceae), is a plant with nutritive, as well as medicinal value. Antihypercholesterolemic and antioxidant effect of methanolic extract of stem of this plant was investigated in hypercholesterolemic rats. Rats were made hypercholesterolemic by feeding cholesterol (100 mg/kg/day) suspended in soya oil. Treatment groups received extract at a dose of 10, 20 and 40 mg/kg/day in addition to cholesterol orally once daily. Fasting blood samples were collected before and after 6 weeks treatment. Animals were sacrificed and liver stored at -80 °C. Total cholesterol, HDL-cholesterol and triacylglycerol were estimated in blood. Malondialdehyde, reduced glutathione, superoxide dismutase and catalase were measured in blood and liver. Total lipids, HMG CoA redutase and lipoprotein lipase were investigated in liver. Most effective dose was found to be 20 mg/kg/day. Rise in total cholesterol, LDL + VLDL-cholesterol and triacylglycerol in animals receiving only cholesterol was 179 %, 417 % and 74 % respectively, while in animals receiving 20 mg/kg dose rise in these parameters was restricted to 40 %, 106 % and 24 %. HDL-cholesterol decreased by 12 % in extract treated group, while it decreased to 36 % in untreated hypercholesterolemic rats. Malonaldialdehyde, marker of lipid peroxidation decreased while reduced glutathione and enzymes superoxide dismutase and catalase increased significantly in blood and liver (p 

Original languageEnglish (US)
Pages (from-to)1690-1697
Number of pages8
JournalJournal of Food Science and Technology
Volume53
Issue number3
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

Keywords

  • Antihypercholesterolemic
  • Antioxidant
  • Gas chromatography mass spectroscopy
  • Lipoprotein lipase
  • Musa sapientum (Msmt)
  • Sterol

ASJC Scopus subject areas

  • Food Science

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