Antimicrobial activity and synergism of Sami-Hyanglyun-Hwan with ciprofloxacin against methicillin-resistant Staphylococcus aureus

Jang Gi Choi, Ji Young Choi, Su Hyun Mun, Ok Hwa Kang, Preeti Bharaj, Dong Won Shin, Myong Soo Chong, Dong Yeul Kwon

Research output: Contribution to journalArticle

4 Scopus citations


Objective: To investigate the antibacterial activity of SHH extracted with either water or ethanol against methicillin-resistant Staphylococcus aureus (MRSA) and combinatory antimicrobial effect with ciprofloxacin (CIP) by time kill assay and checkerboard dilution test. Methods: The antibacterial activity determined by broth dilution method indicated that the antibacterial activity of Sami-Hyanglyun-Hwan (SHH) water extract (SHHW) and SHH ethanol extract (SHHE) ranged from 250 to 2. 000 μg/mL and 125 to 1. 000 μg/mL against MRSA, respectively. Results: In the checkerboard method, the combinations of SHHE with CIP had a partial synergistic or synergistic effect against MRSA. The time-kill curves showed that a combined SHHE and CIP treatment reduced the bacterial counts dramatically after 24 h. Conclusions: The present study demonstrates the therapeutic ability of SHHE against MRSA infections.

Original languageEnglish (US)
Pages (from-to)538-542
Number of pages5
JournalAsian Pacific Journal of Tropical Medicine
Issue number7
StatePublished - Jul 1 2015
Externally publishedYes



  • Ciprofloxacin
  • Methicillin-resistant Staphylococcus aureus
  • Sami-Hyanglyun-Hwan
  • Synergy

ASJC Scopus subject areas

  • Medicine(all)

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