Antimicrobial activity and synergism of Sami-Hyanglyun-Hwan with ciprofloxacin against methicillin-resistant Staphylococcus aureus

Jang Gi Choi, Ji Young Choi, Su Hyun Mun, Ok Hwa Kang, Preeti Bharaj, Dong Won Shin, Myong Soo Chong, Dong Yeul Kwon

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To investigate the antibacterial activity of SHH extracted with either water or ethanol against methicillin-resistant Staphylococcus aureus (MRSA) and combinatory antimicrobial effect with ciprofloxacin (CIP) by time kill assay and checkerboard dilution test. Methods: The antibacterial activity determined by broth dilution method indicated that the antibacterial activity of Sami-Hyanglyun-Hwan (SHH) water extract (SHHW) and SHH ethanol extract (SHHE) ranged from 250 to 2. 000 μg/mL and 125 to 1. 000 μg/mL against MRSA, respectively. Results: In the checkerboard method, the combinations of SHHE with CIP had a partial synergistic or synergistic effect against MRSA. The time-kill curves showed that a combined SHHE and CIP treatment reduced the bacterial counts dramatically after 24 h. Conclusions: The present study demonstrates the therapeutic ability of SHHE against MRSA infections.

Original languageEnglish (US)
Pages (from-to)538-542
Number of pages5
JournalAsian Pacific Journal of Tropical Medicine
Volume8
Issue number7
DOIs
StatePublished - Jul 1 2015
Externally publishedYes

Fingerprint

Methicillin-Resistant Staphylococcus aureus
Ciprofloxacin
Ethanol
Water
Bacterial Load
Infection
Therapeutics

Keywords

  • Ciprofloxacin
  • Methicillin-resistant Staphylococcus aureus
  • Sami-Hyanglyun-Hwan
  • Synergy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Antimicrobial activity and synergism of Sami-Hyanglyun-Hwan with ciprofloxacin against methicillin-resistant Staphylococcus aureus. / Choi, Jang Gi; Choi, Ji Young; Mun, Su Hyun; Kang, Ok Hwa; Bharaj, Preeti; Shin, Dong Won; Chong, Myong Soo; Kwon, Dong Yeul.

In: Asian Pacific Journal of Tropical Medicine, Vol. 8, No. 7, 01.07.2015, p. 538-542.

Research output: Contribution to journalArticle

Choi, Jang Gi ; Choi, Ji Young ; Mun, Su Hyun ; Kang, Ok Hwa ; Bharaj, Preeti ; Shin, Dong Won ; Chong, Myong Soo ; Kwon, Dong Yeul. / Antimicrobial activity and synergism of Sami-Hyanglyun-Hwan with ciprofloxacin against methicillin-resistant Staphylococcus aureus. In: Asian Pacific Journal of Tropical Medicine. 2015 ; Vol. 8, No. 7. pp. 538-542.
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AU - Mun, Su Hyun

AU - Kang, Ok Hwa

AU - Bharaj, Preeti

AU - Shin, Dong Won

AU - Chong, Myong Soo

AU - Kwon, Dong Yeul

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AB - Objective: To investigate the antibacterial activity of SHH extracted with either water or ethanol against methicillin-resistant Staphylococcus aureus (MRSA) and combinatory antimicrobial effect with ciprofloxacin (CIP) by time kill assay and checkerboard dilution test. Methods: The antibacterial activity determined by broth dilution method indicated that the antibacterial activity of Sami-Hyanglyun-Hwan (SHH) water extract (SHHW) and SHH ethanol extract (SHHE) ranged from 250 to 2. 000 μg/mL and 125 to 1. 000 μg/mL against MRSA, respectively. Results: In the checkerboard method, the combinations of SHHE with CIP had a partial synergistic or synergistic effect against MRSA. The time-kill curves showed that a combined SHHE and CIP treatment reduced the bacterial counts dramatically after 24 h. Conclusions: The present study demonstrates the therapeutic ability of SHHE against MRSA infections.

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