Antinuclear antibodies in the serum of normal pregnant women

A prospective study

Jafar Farnam, Marta T. Lavastida, J. Andrew Grant, Renuka C. Reddi, Jerry C. Daniels

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

A prospective study was performed to determine the incidence of antinuclear antibodies in 214 normal pregnant women and in 50 age-matched controls. Serum samples of 23 pregnant women (10.7%) yielded positive results (1+ or more at a dilution of 1:20) in contrast with only one sample (2%) in the control group (p < 0.05). Of the pregnant women found to be positive, five (9.2%) were in the second trimester, and 18 (13.4%) were in the last trimester. Only two also had positive anti-DNA antibodies. A review of their hospital records disclosed no reason to suspect systemic lupus erythematosus or other rheumatologic diseases nor any significant increase in neonatal morbidity of their infants. We conclude that the incidence of antinuclear antibodies in pregnant women is significantly higher than in nonpregnant women and that the finding probably does not correlate with any adverse clinical effect.

Original languageEnglish (US)
Pages (from-to)596-599
Number of pages4
JournalThe Journal of Allergy and Clinical Immunology
Volume73
Issue number5 PART 1
DOIs
StatePublished - 1984

Fingerprint

Antinuclear Antibodies
Pregnant Women
Prospective Studies
Serum
Hospital Records
Incidence
Third Pregnancy Trimester
Second Pregnancy Trimester
Systemic Lupus Erythematosus
Morbidity
Control Groups

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Antinuclear antibodies in the serum of normal pregnant women : A prospective study. / Farnam, Jafar; Lavastida, Marta T.; Grant, J. Andrew; Reddi, Renuka C.; Daniels, Jerry C.

In: The Journal of Allergy and Clinical Immunology, Vol. 73, No. 5 PART 1, 1984, p. 596-599.

Research output: Contribution to journalArticle

Farnam, Jafar ; Lavastida, Marta T. ; Grant, J. Andrew ; Reddi, Renuka C. ; Daniels, Jerry C. / Antinuclear antibodies in the serum of normal pregnant women : A prospective study. In: The Journal of Allergy and Clinical Immunology. 1984 ; Vol. 73, No. 5 PART 1. pp. 596-599.
@article{83b312b5f5a74f5c90607e5d140e5d09,
title = "Antinuclear antibodies in the serum of normal pregnant women: A prospective study",
abstract = "A prospective study was performed to determine the incidence of antinuclear antibodies in 214 normal pregnant women and in 50 age-matched controls. Serum samples of 23 pregnant women (10.7{\%}) yielded positive results (1+ or more at a dilution of 1:20) in contrast with only one sample (2{\%}) in the control group (p < 0.05). Of the pregnant women found to be positive, five (9.2{\%}) were in the second trimester, and 18 (13.4{\%}) were in the last trimester. Only two also had positive anti-DNA antibodies. A review of their hospital records disclosed no reason to suspect systemic lupus erythematosus or other rheumatologic diseases nor any significant increase in neonatal morbidity of their infants. We conclude that the incidence of antinuclear antibodies in pregnant women is significantly higher than in nonpregnant women and that the finding probably does not correlate with any adverse clinical effect.",
author = "Jafar Farnam and Lavastida, {Marta T.} and Grant, {J. Andrew} and Reddi, {Renuka C.} and Daniels, {Jerry C.}",
year = "1984",
doi = "10.1016/0091-6749(84)90517-7",
language = "English (US)",
volume = "73",
pages = "596--599",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "5 PART 1",

}

TY - JOUR

T1 - Antinuclear antibodies in the serum of normal pregnant women

T2 - A prospective study

AU - Farnam, Jafar

AU - Lavastida, Marta T.

AU - Grant, J. Andrew

AU - Reddi, Renuka C.

AU - Daniels, Jerry C.

PY - 1984

Y1 - 1984

N2 - A prospective study was performed to determine the incidence of antinuclear antibodies in 214 normal pregnant women and in 50 age-matched controls. Serum samples of 23 pregnant women (10.7%) yielded positive results (1+ or more at a dilution of 1:20) in contrast with only one sample (2%) in the control group (p < 0.05). Of the pregnant women found to be positive, five (9.2%) were in the second trimester, and 18 (13.4%) were in the last trimester. Only two also had positive anti-DNA antibodies. A review of their hospital records disclosed no reason to suspect systemic lupus erythematosus or other rheumatologic diseases nor any significant increase in neonatal morbidity of their infants. We conclude that the incidence of antinuclear antibodies in pregnant women is significantly higher than in nonpregnant women and that the finding probably does not correlate with any adverse clinical effect.

AB - A prospective study was performed to determine the incidence of antinuclear antibodies in 214 normal pregnant women and in 50 age-matched controls. Serum samples of 23 pregnant women (10.7%) yielded positive results (1+ or more at a dilution of 1:20) in contrast with only one sample (2%) in the control group (p < 0.05). Of the pregnant women found to be positive, five (9.2%) were in the second trimester, and 18 (13.4%) were in the last trimester. Only two also had positive anti-DNA antibodies. A review of their hospital records disclosed no reason to suspect systemic lupus erythematosus or other rheumatologic diseases nor any significant increase in neonatal morbidity of their infants. We conclude that the incidence of antinuclear antibodies in pregnant women is significantly higher than in nonpregnant women and that the finding probably does not correlate with any adverse clinical effect.

UR - http://www.scopus.com/inward/record.url?scp=0021331306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021331306&partnerID=8YFLogxK

U2 - 10.1016/0091-6749(84)90517-7

DO - 10.1016/0091-6749(84)90517-7

M3 - Article

VL - 73

SP - 596

EP - 599

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 5 PART 1

ER -