Antiphospholipid antibodies and APS nephropathy

Rohan Willis, Emilio Gonzalez

Research output: Contribution to journalArticle

Abstract

The presence of pathogenic antiphospholipid antibodies (aPL) is the characterizing feature of the antiphospholipid syndrome (APS), mediating the recurrent pregnancy loss and thrombosis typical of the disease through its action on various antigenic targets. APS nephropathy is the characteristic clinico-pathological manifestation of renal involvement in APS and occurs as a result of vaso-occlusive disease in the intrarenal vasculature. The typical clinical features and morphological lesions of APS nephropathy have been well characterized and several studies have established a link between these features and the presence of various aPL. In this review, we outline the proposed pathophysiological mechanisms of aPL-mediated thrombosis, the characteristic clinical and morphological features of APS nephropathy and the evidence linking aPL action to the occurrence of APS nephropathy.

Original languageEnglish (US)
Pages (from-to)10-17
Number of pages8
JournalOpen Urology and Nephrology Journal
Volume8
StatePublished - 2015

Keywords

  • Antiphospholipid antibodies
  • Antiphospholipid syndrome
  • Nephropathy

ASJC Scopus subject areas

  • Nephrology
  • Urology

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