Antithrombin in burn trauma

P. Enkhbaatar, L. D. Traber, D. L. Traber

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

In the United States, more than 1 million burn injuries occur every year. Although the survival from burn injury has increased in recent years with the development of effective fluid resuscitation management and early surgical excision of burned tissue, the mortality of burn injury is still high. In these fire victims, progressive pulmonary failure and cardiovascular dysfunction are important determinants of morbidity and mortality. The morbidity and mortality increases when burn injury is associated with smoke inhalation. Smoke inhalation and pneumonia increase mortality of burn patients by 20 and 40%, respectively [1], suggesting that the pulmonary involvement is a very important risk factor in burn trauma. Our group and others have reported various factors that are involved in pathophysiology of acute lung injury (ALI) in burn, including coagulopathy [2, 3]. It was earlier described that burn injury is associated with a hypercoagulable state [4]. The coagulopathy seen in these burn patients is associated with marked depletion of a major endogenous regulator of blood coagulation, antithrombin [3]-[5]. In the present chapter, we will discuss a possible role of antithrombin in the pathophysiology of ALI induced by combined burn and smoke inhalation and review the therapeutic approaches.

Original languageEnglish (US)
Title of host publicationIntensive Care Medicine
Subtitle of host publicationAnnual Update 2007
PublisherSpringer New York
Pages791-796
Number of pages6
ISBN (Print)0387495177, 9780387495170
DOIs
StatePublished - Dec 1 2007

ASJC Scopus subject areas

  • Medicine(all)

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