@article{4de4a7e29410406b89a258a9e375cf9a,
title = "Antiviral activities of type I interferons to SARS-CoV-2 infection",
abstract = "There is an urgent need to identify antivirals to curtail the COVID-19 pandemic. Herein, we report the sensitivity of SARS-CoV-2 to recombinant human interferons α and β (IFNα/β). Treatment with IFN-α or IFN-β at a concentration of 50 international units (IU) per milliliter reduces viral titers by 3.4 log or over 4 log, respectively, in Vero cells. The EC50 of IFN-α and IFN-β treatment is 1.35 IU/ml and 0.76 IU/ml, respectively, in Vero cells. These results suggest that SARS-CoV-2 is more sensitive than many other human pathogenic viruses, including SARS-CoV. Overall, our results demonstrate the potential efficacy of human Type I IFN in suppressing SARS-CoV-2 infection, a finding which could inform future treatment options for COVID-19.",
keywords = "Antiviral therapy, COVID-19, Innate immune, Interferon, SARS-CoV-2",
author = "Emily Mantlo and Natalya Bukreyeva and Junki Maruyama and Slobodan Paessler and Cheng Huang",
note = "Funding Information: We thank Drs. Kenneth Plante (The World Reference Center for Emerging Viruses and Arboviruses, UTMB) and Natalie Thornburg from the CDC for providing the SARS-CoV-2 stock virus. E.K.M was supported by NIH T32 training grant AI060549 . Work in the Paessler laboratory was supported in parts by Public Health Service grants RO1AI093445 and RO1AI129198 and the John. S. Dunn Distinguished Chair in Biodefense endowment. C.H. was supported by UTMB Commitment Fund P84373 and Department of Pathology Pilot Grant and would like to acknowledge the Galveston National Laboratory (supported by the Public Health Service award 5UC7AI094660 ) for support of his research activity. Funding Information: We thank Drs. Kenneth Plante (The World Reference Center for Emerging Viruses and Arboviruses, UTMB) and Natalie Thornburg from the CDC for providing the SARS-CoV-2 stock virus. E.K.M was supported by NIH T32 training grant AI060549. Work in the Paessler laboratory was supported in parts by Public Health Service grants RO1AI093445 and RO1AI129198 and the John. S. Dunn Distinguished Chair in Biodefense endowment. C.H. was supported by UTMB Commitment Fund P84373 and Department of Pathology Pilot Grant and would like to acknowledge the Galveston National Laboratory (supported by the Public Health Service award 5UC7AI094660) for support of his research activity. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",
year = "2020",
month = jul,
doi = "10.1016/j.antiviral.2020.104811",
language = "English (US)",
volume = "179",
journal = "Antiviral Research",
issn = "0166-3542",
publisher = "Elsevier",
}