Antiviral activity of baicalin against influenza virus H1N1-pdm09 is due to modulation of NS1-mediated cellular innate immune responses

Immunology and Microbiology

• Innate Immune System 100%
• Influenzavirus A 100%
• Antiviral Activity 100%
• RNA Recognition Motif 100%
• Influenza A Virus (H1N1) 100%
• Influenza 75%
• Upregulation 50%
• interferon 50%
• Molecular Docking 50%
• Viral Disease 25%
• Immune Response 25%
• Site Directed Mutagenesis 25%
• Viral Protein 25%
• Real-Time Polymerase Chain Reaction 25%
• Western Blot 25%
• Binding Site 25%
• Immunoprecipitation 25%
• Influenza Virus 25%
• Antiinflammatory Activity 25%
• Viral Nonstructural Protein 25%
• Akt Signaling 25%
• Interferon Induction 25%
• Pi3K/Akt Signaling 25%

Keyphrases

• Non-structural Protein 100%
• Antiviral Activity 100%
• Influenza A (H1N1) Virus 100%
• Baicalin 100%
• Eastern India 100%
• A(H1N1)pdm09 100%
• Cellular Innate Immune Response 100%
• RNA-binding Domain 30%
• Influenza Virus 23%
• Phosphoinositide 3-kinase (PI3K) 15%
• Interferon-α (IFN-α) 15%
• Molecular Docking 15%
• Anti-influenza 15%
• Site-directed mutagenesis 7%
• Co-immunoprecipitation (co-IP) 7%
• Mechanism of Action 7%
• Viral Proteins 7%
• Amino Acid Residues 7%
• Quantitative PCR 7%
• Host Response 7%
• Binding Site 7%
• Immunoblotting 7%
• Virus Model 7%
• Influenza-like Illness 7%
• Anti-inflammatory Activity 7%
• AKT Pathway 7%
• Focus-forming Units 7%
• Flavonoids 7%
• Fluorescence Quenching 7%
• Cellular Antiviral Response 7%
• Viral Transcripts 7%
• Pandemic Influenza Virus 7%
• Interferon Induction 7%
• Akt Activation 7%
• Influenza Strains 7%
• Model in Vitro 7%
• PI3K Signaling 7%
• Anti-influenza Virus Activity 7%
• A(H1N1) 7%
• Plaque Inhibition 7%