Antiviral and interferon inducing activity of a new glutarimide antibiotic, 9 methylstreptimidone

N. Saito, Fujio Suzuki, K. Sasaki, N. Ishida

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The antiviral effect of 9 methylstreptimidone (9 MS) was examined in mice infected with mouse adapted influenza A2 (H2N2) virus. Both a single and continuous prophylactic administration of 9 MS protected mice from virus infection, and comparison between the minimal effective and the 50% lethal dose gave a therapeutic index of 60. When the treatment was started after infection, however, no antiviral effect was demonstrated. After a single intraperitoneal administration of 9 MS, a highly potent virus inhibitory factor was detected in the lungs (10 h later) and the sera (16 h later) of uninfected mice, which was assumed to be an interferon on the basis of the biological characteristics. These results suggest that the protective activity of the antibiotic is due to interferon induction in mice.

Original languageEnglish (US)
Pages (from-to)14-19
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Volume10
Issue number1
StatePublished - 1976
Externally publishedYes

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Interferons
Antiviral Agents
Anti-Bacterial Agents
H2N2 Subtype Influenza A Virus
Lethal Dose 50
Virus Diseases
varespladib methyl
Human Influenza
9-methylstreptimidone
glutarimide
Viruses
Lung
Infection
Serum
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Antiviral and interferon inducing activity of a new glutarimide antibiotic, 9 methylstreptimidone. / Saito, N.; Suzuki, Fujio; Sasaki, K.; Ishida, N.

In: Antimicrobial Agents and Chemotherapy, Vol. 10, No. 1, 1976, p. 14-19.

Research output: Contribution to journalArticle

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