AP-2 makes room for rivals

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Clathrin and the adaptor protein complex (AP-2) constitute the major coat components of clathrin-coated vesicles. In the September issues of the Journal of Cell Biology and the Journal of Biological Chemistry, three reports reveal that AP-2, while essential for internalization of transferrin, is not essential for internalization of EGF. These novel data suggest the intriguing possibility that the major role of AP-2 is in cargo recruitment, and not in assembly of functionally active clathrin-coated pits.

Original languageEnglish (US)
Pages (from-to)530-532
Number of pages3
JournalDevelopmental cell
Issue number4
StatePublished - Oct 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • General Biochemistry, Genetics and Molecular Biology
  • Developmental Biology
  • Cell Biology


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