AP-2 makes room for rivals

Sanja Sever

doi:10.1016/S1534-5807(03)00304-6

AP-2 makes room for rivals

Sanja Sever

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Clathrin and the adaptor protein complex (AP-2) constitute the major coat components of clathrin-coated vesicles. In the September issues of the Journal of Cell Biology and the Journal of Biological Chemistry, three reports reveal that AP-2, while essential for internalization of transferrin, is not essential for internalization of EGF. These novel data suggest the intriguing possibility that the major role of AP-2 is in cargo recruitment, and not in assembly of functionally active clathrin-coated pits.

Original language	English (US)
Pages (from-to)	530-532
Number of pages	3
Journal	Developmental cell
Volume	5
Issue number	4
DOIs	https://doi.org/10.1016/S1534-5807(03)00304-6
State	Published - Oct 1 2003
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/S1534-5807(03)00304-6

Cite this

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title = "AP-2 makes room for rivals",

abstract = "Clathrin and the adaptor protein complex (AP-2) constitute the major coat components of clathrin-coated vesicles. In the September issues of the Journal of Cell Biology and the Journal of Biological Chemistry, three reports reveal that AP-2, while essential for internalization of transferrin, is not essential for internalization of EGF. These novel data suggest the intriguing possibility that the major role of AP-2 is in cargo recruitment, and not in assembly of functionally active clathrin-coated pits.",

author = "Sanja Sever",

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AB - Clathrin and the adaptor protein complex (AP-2) constitute the major coat components of clathrin-coated vesicles. In the September issues of the Journal of Cell Biology and the Journal of Biological Chemistry, three reports reveal that AP-2, while essential for internalization of transferrin, is not essential for internalization of EGF. These novel data suggest the intriguing possibility that the major role of AP-2 is in cargo recruitment, and not in assembly of functionally active clathrin-coated pits.

UR - https://www.scopus.com/pages/publications/0141920733

UR - https://www.scopus.com/pages/publications/0141920733#tab=citedBy

U2 - 10.1016/S1534-5807(03)00304-6

DO - 10.1016/S1534-5807(03)00304-6

M3 - Review article

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AN - SCOPUS:0141920733

SN - 1534-5807

VL - 5

SP - 530

EP - 532

JO - Developmental cell

JF - Developmental cell

IS - 4

ER -

AP-2 makes room for rivals

Abstract

ASJC Scopus subject areas

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