Apelin cells in the rat stomach

Etsuko Susaki, Guiyun Wang, Gan Cao, Hui Quin Wang, Ella Englander, George H. Greeley

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Apelin is a recently discovered peptide that is the endogenous ligand for the APJ receptor. Apelin is produced in the central nervous system, heart, lung, mammary gland and gastrointestinal (GI) tract. The aim of this study was to identify by immunohistochemistry (IHC) cell types in the rat stomach that produce apelin peptide. IHC revealed abundant apelin-positive cells, primarily in the neck and upper base regions of the gastric glands in the mucosal epithelium. Apelin is not detected in the muscle layer. Apelin-positive cells were identified as mucous neck, parietal cells, and chief cells. Apelin is also identified in gastric epithelial cells that produce chromogranin A (CGA), a marker of enteroendocrine cells. The findings that apelin is expressed in gastric exocrine and endocrine cells agrees with and extends other data showing that apelin peptide is measurable in the gut lumen and in the systemic circulation by immunoassay.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
JournalRegulatory Peptides
Volume129
Issue number1-3
DOIs
StatePublished - Jul 15 2005

Fingerprint

Rats
Stomach
Cells
Peptides
Chromogranin A
Neurology
Neck
Immunohistochemistry
Muscle
Enteroendocrine Cells
Endocrine Cells
Ligands
Human Mammary Glands
Gastric Mucosa
Immunoassay
Gastrointestinal Tract
Epithelium
Central Nervous System
Epithelial Cells
Muscles

Keywords

  • Chromogranin A
  • Endocrine cells
  • Exocrine cells
  • Expression

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

Susaki, E., Wang, G., Cao, G., Wang, H. Q., Englander, E., & Greeley, G. H. (2005). Apelin cells in the rat stomach. Regulatory Peptides, 129(1-3), 37-41. https://doi.org/10.1016/j.regpep.2005.01.013

Apelin cells in the rat stomach. / Susaki, Etsuko; Wang, Guiyun; Cao, Gan; Wang, Hui Quin; Englander, Ella; Greeley, George H.

In: Regulatory Peptides, Vol. 129, No. 1-3, 15.07.2005, p. 37-41.

Research output: Contribution to journalArticle

Susaki, E, Wang, G, Cao, G, Wang, HQ, Englander, E & Greeley, GH 2005, 'Apelin cells in the rat stomach', Regulatory Peptides, vol. 129, no. 1-3, pp. 37-41. https://doi.org/10.1016/j.regpep.2005.01.013
Susaki E, Wang G, Cao G, Wang HQ, Englander E, Greeley GH. Apelin cells in the rat stomach. Regulatory Peptides. 2005 Jul 15;129(1-3):37-41. https://doi.org/10.1016/j.regpep.2005.01.013
Susaki, Etsuko ; Wang, Guiyun ; Cao, Gan ; Wang, Hui Quin ; Englander, Ella ; Greeley, George H. / Apelin cells in the rat stomach. In: Regulatory Peptides. 2005 ; Vol. 129, No. 1-3. pp. 37-41.
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