Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals

Sarah A. Cooley; Robert H. Paul; Christine Fennema-Notestine; Erin E. Morgan; Florin Vaida; Qianqian Deng; Jie Ashley Chen; Scott Letendre; Ronald Ellis; David B. Clifford; Christina M. Marra; Ann C. Collier; Benjamin Gelman; Justin C. McArthur; J. Allen McCutchan; David M. Simpson; Susan Morgello; Igor Grant; Beau M. Ances; The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group For The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group

doi:10.1007/s13365-016-0434-7

Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals

Sarah A. Cooley, Robert H. Paul, Christine Fennema-Notestine, Erin E. Morgan, Florin Vaida, Qianqian Deng, Jie Ashley Chen, Scott Letendre, Ronald Ellis, David B. Clifford, Christina M. Marra, Ann C. Collier, Benjamin Gelman, Justin C. McArthur, J. Allen McCutchan, David M. Simpson, Susan Morgello, Igor Grant, Beau M. Ances, The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group For The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group

Pathology

Research output: Contribution to journal › Article

8 Scopus citations

Abstract

Previous neuroimaging studies suggest a negative relationship between the apolipoprotein (ApoE) ε4 allele and brain integrity in human immunodeficiency virus (HIV)-infected (HIV+) individuals, although the presence of this relationship across adulthood remains unclear. The purpose of this study is to clarify the discrepancies using a large, diverse group of HIV+ individuals and multiple imaging modalities sensitive to HIV. The association of ApoE ε4 with structural neuroimaging and magnetic resonance spectroscopy (MRS) was examined in 237 HIV+ individuals in the CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) study. Cortical and subcortical gray matter, abnormal and total white matter, ventricles, sulcal cerebrospinal fluid (CSF), and cerebellar gray matter, white matter, and CSF volumes, and MRS concentrations of myo-inositol, creatine, N-acetyl-aspartate, and choline in the frontal white matter (FWM), frontal gray matter (FGM), and basal ganglia were examined. Secondary analyses explored this relationship separately in individuals ≥50 years old (n = 173) and

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Journal of NeuroVirology
DOIs	https://doi.org/10.1007/s13365-016-0434-7
State	Accepted/In press - Mar 28 2016

Fingerprint

Keywords

Brain volumetrics
Genetics
HIV/AIDS
Magnetic resonance spectroscopy

ASJC Scopus subject areas

Virology
Clinical Neurology
Cellular and Molecular Neuroscience
Neurology

Cite this

Cooley, S. A., Paul, R. H., Fennema-Notestine, C., Morgan, E. E., Vaida, F., Deng, Q., Chen, J. A., Letendre, S., Ellis, R., Clifford, D. B., Marra, C. M., Collier, A. C., Gelman, B., McArthur, J. C., McCutchan, J. A., Simpson, D. M., Morgello, S., Grant, I., Ances, B. M., & For The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group, T. C. H. A-R. T. E. R. C. G. (Accepted/In press). Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals. Journal of NeuroVirology, 1-8. https://doi.org/10.1007/s13365-016-0434-7

Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals. / Cooley, Sarah A.; Paul, Robert H.; Fennema-Notestine, Christine; Morgan, Erin E.; Vaida, Florin; Deng, Qianqian; Chen, Jie Ashley; Letendre, Scott; Ellis, Ronald; Clifford, David B.; Marra, Christina M.; Collier, Ann C.; Gelman, Benjamin; McArthur, Justin C.; McCutchan, J. Allen; Simpson, David M.; Morgello, Susan; Grant, Igor; Ances, Beau M.; For The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group, The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group.

In: Journal of NeuroVirology, 28.03.2016, p. 1-8.

Research output: Contribution to journal › Article

Cooley, SA, Paul, RH, Fennema-Notestine, C, Morgan, EE, Vaida, F, Deng, Q, Chen, JA, Letendre, S, Ellis, R, Clifford, DB, Marra, CM, Collier, AC, Gelman, B, McArthur, JC, McCutchan, JA, Simpson, DM, Morgello, S, Grant, I, Ances, BM & For The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group, TCHA-RTERCG 2016, 'Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals', Journal of NeuroVirology, pp. 1-8. https://doi.org/10.1007/s13365-016-0434-7

Cooley, Sarah A. ; Paul, Robert H. ; Fennema-Notestine, Christine ; Morgan, Erin E. ; Vaida, Florin ; Deng, Qianqian ; Chen, Jie Ashley ; Letendre, Scott ; Ellis, Ronald ; Clifford, David B. ; Marra, Christina M. ; Collier, Ann C. ; Gelman, Benjamin ; McArthur, Justin C. ; McCutchan, J. Allen ; Simpson, David M. ; Morgello, Susan ; Grant, Igor ; Ances, Beau M. ; For The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group, The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group. / Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals. In: Journal of NeuroVirology. 2016 ; pp. 1-8.

@article{8f93337694b44ebb9730eecdcd606f46,

title = "Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals",

abstract = "Previous neuroimaging studies suggest a negative relationship between the apolipoprotein (ApoE) ε4 allele and brain integrity in human immunodeficiency virus (HIV)-infected (HIV+) individuals, although the presence of this relationship across adulthood remains unclear. The purpose of this study is to clarify the discrepancies using a large, diverse group of HIV+ individuals and multiple imaging modalities sensitive to HIV. The association of ApoE ε4 with structural neuroimaging and magnetic resonance spectroscopy (MRS) was examined in 237 HIV+ individuals in the CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) study. Cortical and subcortical gray matter, abnormal and total white matter, ventricles, sulcal cerebrospinal fluid (CSF), and cerebellar gray matter, white matter, and CSF volumes, and MRS concentrations of myo-inositol, creatine, N-acetyl-aspartate, and choline in the frontal white matter (FWM), frontal gray matter (FGM), and basal ganglia were examined. Secondary analyses explored this relationship separately in individuals ≥50 years old (n = 173) and ",

keywords = "Brain volumetrics, Genetics, HIV/AIDS, Magnetic resonance spectroscopy",

author = "Cooley, {Sarah A.} and Paul, {Robert H.} and Christine Fennema-Notestine and Morgan, {Erin E.} and Florin Vaida and Qianqian Deng and Chen, {Jie Ashley} and Scott Letendre and Ronald Ellis and Clifford, {David B.} and Marra, {Christina M.} and Collier, {Ann C.} and Benjamin Gelman and McArthur, {Justin C.} and McCutchan, {J. Allen} and Simpson, {David M.} and Susan Morgello and Igor Grant and Ances, {Beau M.} and {For The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group}, {The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group}",

year = "2016",

month = mar

day = "28",

doi = "10.1007/s13365-016-0434-7",

language = "English (US)",

pages = "1--8",

journal = "Journal of NeuroVirology",

issn = "1355-0284",

publisher = "Springer New York",

}

TY - JOUR

T1 - Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals

AU - Cooley, Sarah A.

AU - Paul, Robert H.

AU - Fennema-Notestine, Christine

AU - Morgan, Erin E.

AU - Vaida, Florin

AU - Deng, Qianqian

AU - Chen, Jie Ashley

AU - Letendre, Scott

AU - Ellis, Ronald

AU - Clifford, David B.

AU - Marra, Christina M.

AU - Collier, Ann C.

AU - Gelman, Benjamin

AU - McArthur, Justin C.

AU - McCutchan, J. Allen

AU - Simpson, David M.

AU - Morgello, Susan

AU - Grant, Igor

AU - Ances, Beau M.

AU - For The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group, The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group

PY - 2016/3/28

Y1 - 2016/3/28

N2 - Previous neuroimaging studies suggest a negative relationship between the apolipoprotein (ApoE) ε4 allele and brain integrity in human immunodeficiency virus (HIV)-infected (HIV+) individuals, although the presence of this relationship across adulthood remains unclear. The purpose of this study is to clarify the discrepancies using a large, diverse group of HIV+ individuals and multiple imaging modalities sensitive to HIV. The association of ApoE ε4 with structural neuroimaging and magnetic resonance spectroscopy (MRS) was examined in 237 HIV+ individuals in the CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) study. Cortical and subcortical gray matter, abnormal and total white matter, ventricles, sulcal cerebrospinal fluid (CSF), and cerebellar gray matter, white matter, and CSF volumes, and MRS concentrations of myo-inositol, creatine, N-acetyl-aspartate, and choline in the frontal white matter (FWM), frontal gray matter (FGM), and basal ganglia were examined. Secondary analyses explored this relationship separately in individuals ≥50 years old (n = 173) and

AB - Previous neuroimaging studies suggest a negative relationship between the apolipoprotein (ApoE) ε4 allele and brain integrity in human immunodeficiency virus (HIV)-infected (HIV+) individuals, although the presence of this relationship across adulthood remains unclear. The purpose of this study is to clarify the discrepancies using a large, diverse group of HIV+ individuals and multiple imaging modalities sensitive to HIV. The association of ApoE ε4 with structural neuroimaging and magnetic resonance spectroscopy (MRS) was examined in 237 HIV+ individuals in the CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) study. Cortical and subcortical gray matter, abnormal and total white matter, ventricles, sulcal cerebrospinal fluid (CSF), and cerebellar gray matter, white matter, and CSF volumes, and MRS concentrations of myo-inositol, creatine, N-acetyl-aspartate, and choline in the frontal white matter (FWM), frontal gray matter (FGM), and basal ganglia were examined. Secondary analyses explored this relationship separately in individuals ≥50 years old (n = 173) and

KW - Brain volumetrics

KW - Genetics

KW - HIV/AIDS

KW - Magnetic resonance spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=84961631521&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961631521&partnerID=8YFLogxK

U2 - 10.1007/s13365-016-0434-7

DO - 10.1007/s13365-016-0434-7

M3 - Article

C2 - 27021072

AN - SCOPUS:84961631521

SP - 1

EP - 8

JO - Journal of NeuroVirology

JF - Journal of NeuroVirology

SN - 1355-0284

ER -

Access to Document

10.1007/s13365-016-0434-7