Abstract
Previous neuroimaging studies suggest a negative relationship between the apolipoprotein (ApoE) ε4 allele and brain integrity in human immunodeficiency virus (HIV)-infected (HIV+) individuals, although the presence of this relationship across adulthood remains unclear. The purpose of this study is to clarify the discrepancies using a large, diverse group of HIV+ individuals and multiple imaging modalities sensitive to HIV. The association of ApoE ε4 with structural neuroimaging and magnetic resonance spectroscopy (MRS) was examined in 237 HIV+ individuals in the CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) study. Cortical and subcortical gray matter, abnormal and total white matter, ventricles, sulcal cerebrospinal fluid (CSF), and cerebellar gray matter, white matter, and CSF volumes, and MRS concentrations of myo-inositol, creatine, N-acetyl-aspartate, and choline in the frontal white matter (FWM), frontal gray matter (FGM), and basal ganglia were examined. Secondary analyses explored this relationship separately in individuals ≥50 years old (n = 173) and
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-8 |
| Number of pages | 8 |
| Journal | Journal of NeuroVirology |
| DOIs | |
| State | Accepted/In press - Mar 28 2016 |
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Keywords
- Brain volumetrics
- Genetics
- HIV/AIDS
- Magnetic resonance spectroscopy
ASJC Scopus subject areas
- Virology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Neurology
Cite this
Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals. / Cooley, Sarah A.; Paul, Robert H.; Fennema-Notestine, Christine; Morgan, Erin E.; Vaida, Florin; Deng, Qianqian; Chen, Jie Ashley; Letendre, Scott; Ellis, Ronald; Clifford, David B.; Marra, Christina M.; Collier, Ann C.; Gelman, Benjamin; McArthur, Justin C.; McCutchan, J. Allen; Simpson, David M.; Morgello, Susan; Grant, Igor; Ances, Beau M.; For The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group, The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group.
In: Journal of NeuroVirology, 28.03.2016, p. 1-8.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals
AU - Cooley, Sarah A.
AU - Paul, Robert H.
AU - Fennema-Notestine, Christine
AU - Morgan, Erin E.
AU - Vaida, Florin
AU - Deng, Qianqian
AU - Chen, Jie Ashley
AU - Letendre, Scott
AU - Ellis, Ronald
AU - Clifford, David B.
AU - Marra, Christina M.
AU - Collier, Ann C.
AU - Gelman, Benjamin
AU - McArthur, Justin C.
AU - McCutchan, J. Allen
AU - Simpson, David M.
AU - Morgello, Susan
AU - Grant, Igor
AU - Ances, Beau M.
AU - For The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group, The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group
PY - 2016/3/28
Y1 - 2016/3/28
N2 - Previous neuroimaging studies suggest a negative relationship between the apolipoprotein (ApoE) ε4 allele and brain integrity in human immunodeficiency virus (HIV)-infected (HIV+) individuals, although the presence of this relationship across adulthood remains unclear. The purpose of this study is to clarify the discrepancies using a large, diverse group of HIV+ individuals and multiple imaging modalities sensitive to HIV. The association of ApoE ε4 with structural neuroimaging and magnetic resonance spectroscopy (MRS) was examined in 237 HIV+ individuals in the CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) study. Cortical and subcortical gray matter, abnormal and total white matter, ventricles, sulcal cerebrospinal fluid (CSF), and cerebellar gray matter, white matter, and CSF volumes, and MRS concentrations of myo-inositol, creatine, N-acetyl-aspartate, and choline in the frontal white matter (FWM), frontal gray matter (FGM), and basal ganglia were examined. Secondary analyses explored this relationship separately in individuals ≥50 years old (n = 173) and
AB - Previous neuroimaging studies suggest a negative relationship between the apolipoprotein (ApoE) ε4 allele and brain integrity in human immunodeficiency virus (HIV)-infected (HIV+) individuals, although the presence of this relationship across adulthood remains unclear. The purpose of this study is to clarify the discrepancies using a large, diverse group of HIV+ individuals and multiple imaging modalities sensitive to HIV. The association of ApoE ε4 with structural neuroimaging and magnetic resonance spectroscopy (MRS) was examined in 237 HIV+ individuals in the CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) study. Cortical and subcortical gray matter, abnormal and total white matter, ventricles, sulcal cerebrospinal fluid (CSF), and cerebellar gray matter, white matter, and CSF volumes, and MRS concentrations of myo-inositol, creatine, N-acetyl-aspartate, and choline in the frontal white matter (FWM), frontal gray matter (FGM), and basal ganglia were examined. Secondary analyses explored this relationship separately in individuals ≥50 years old (n = 173) and
KW - Brain volumetrics
KW - Genetics
KW - HIV/AIDS
KW - Magnetic resonance spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=84961631521&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961631521&partnerID=8YFLogxK
U2 - 10.1007/s13365-016-0434-7
DO - 10.1007/s13365-016-0434-7
M3 - Article
SP - 1
EP - 8
JO - Journal of NeuroVirology
JF - Journal of NeuroVirology
SN - 1355-0284
ER -