Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals

Sarah A. Cooley, Robert H. Paul, Christine Fennema-Notestine, Erin E. Morgan, Florin Vaida, Qianqian Deng, Jie Ashley Chen, Scott Letendre, Ronald Ellis, David B. Clifford, Christina M. Marra, Ann C. Collier, Benjamin Gelman, Justin C. McArthur, J. Allen McCutchan, David M. Simpson, Susan Morgello, Igor Grant, Beau M. Ances, The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group For The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Previous neuroimaging studies suggest a negative relationship between the apolipoprotein (ApoE) ε4 allele and brain integrity in human immunodeficiency virus (HIV)-infected (HIV+) individuals, although the presence of this relationship across adulthood remains unclear. The purpose of this study is to clarify the discrepancies using a large, diverse group of HIV+ individuals and multiple imaging modalities sensitive to HIV. The association of ApoE ε4 with structural neuroimaging and magnetic resonance spectroscopy (MRS) was examined in 237 HIV+ individuals in the CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) study. Cortical and subcortical gray matter, abnormal and total white matter, ventricles, sulcal cerebrospinal fluid (CSF), and cerebellar gray matter, white matter, and CSF volumes, and MRS concentrations of myo-inositol, creatine, N-acetyl-aspartate, and choline in the frontal white matter (FWM), frontal gray matter (FGM), and basal ganglia were examined. Secondary analyses explored this relationship separately in individuals ≥50 years old (n = 173) and

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalJournal of NeuroVirology
DOIs
StateAccepted/In press - Mar 28 2016

Keywords

  • Brain volumetrics
  • Genetics
  • HIV/AIDS
  • Magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Neurology

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  • Cite this

    Cooley, S. A., Paul, R. H., Fennema-Notestine, C., Morgan, E. E., Vaida, F., Deng, Q., Chen, J. A., Letendre, S., Ellis, R., Clifford, D. B., Marra, C. M., Collier, A. C., Gelman, B., McArthur, J. C., McCutchan, J. A., Simpson, D. M., Morgello, S., Grant, I., Ances, B. M., & For The Cns Hiv Anti-Retroviral Therapy Effects Research (Charter) Group, T. C. H. A-R. T. E. R. C. G. (Accepted/In press). Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals. Journal of NeuroVirology, 1-8. https://doi.org/10.1007/s13365-016-0434-7