Apoptosis in prostate cancer

progressive and therapeutic implications (Review).

Gangduo Wang, Eddie Reed, Qingdi Q. Li

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Prostate cancer is the most common non-cutaneous malignancy in American men and the second greatest cause of cancer-related death. Development of effective therapeutic modalities for the treatment of this cancer relies heavily on understanding the molecular alterations that result in the initiation and progression of the tumorigenic process. Increasing evidence indicates that impaired ability to undergo apoptosis plays an important role in the evolution from androgen-dependent to androgen-independent prostate cancer. In this review, we address recent progress toward the central objectives of understanding the molecular events that contribute to prostate cancer progression. We focus on some key regulatory molecules, including the pro-apoptotic regulators p53, PTEN, caspases and Par-4, and the anti-apoptotic molecules Bcl-2, NF-kappaB and Akt, to discuss their roles in prostate cancer progression and their therapeutic implications in human prostate carcinoma.

Original languageEnglish (US)
Pages (from-to)23-34
Number of pages12
JournalInternational Journal of Molecular Medicine
Volume14
Issue number1
StatePublished - Jul 2004
Externally publishedYes

Fingerprint

Prostatic Neoplasms
Apoptosis
Androgens
Neoplasms
NF-kappa B
Therapeutics
Caspases
Prostate
Carcinoma

ASJC Scopus subject areas

  • Genetics

Cite this

Apoptosis in prostate cancer : progressive and therapeutic implications (Review). / Wang, Gangduo; Reed, Eddie; Li, Qingdi Q.

In: International Journal of Molecular Medicine, Vol. 14, No. 1, 07.2004, p. 23-34.

Research output: Contribution to journalArticle

@article{c8d6544d943e4058b8162e1f51c583e7,
title = "Apoptosis in prostate cancer: progressive and therapeutic implications (Review).",
abstract = "Prostate cancer is the most common non-cutaneous malignancy in American men and the second greatest cause of cancer-related death. Development of effective therapeutic modalities for the treatment of this cancer relies heavily on understanding the molecular alterations that result in the initiation and progression of the tumorigenic process. Increasing evidence indicates that impaired ability to undergo apoptosis plays an important role in the evolution from androgen-dependent to androgen-independent prostate cancer. In this review, we address recent progress toward the central objectives of understanding the molecular events that contribute to prostate cancer progression. We focus on some key regulatory molecules, including the pro-apoptotic regulators p53, PTEN, caspases and Par-4, and the anti-apoptotic molecules Bcl-2, NF-kappaB and Akt, to discuss their roles in prostate cancer progression and their therapeutic implications in human prostate carcinoma.",
author = "Gangduo Wang and Eddie Reed and Li, {Qingdi Q.}",
year = "2004",
month = "7",
language = "English (US)",
volume = "14",
pages = "23--34",
journal = "International Journal of Molecular Medicine",
issn = "1107-3756",
publisher = "Spandidos Publications",
number = "1",

}

TY - JOUR

T1 - Apoptosis in prostate cancer

T2 - progressive and therapeutic implications (Review).

AU - Wang, Gangduo

AU - Reed, Eddie

AU - Li, Qingdi Q.

PY - 2004/7

Y1 - 2004/7

N2 - Prostate cancer is the most common non-cutaneous malignancy in American men and the second greatest cause of cancer-related death. Development of effective therapeutic modalities for the treatment of this cancer relies heavily on understanding the molecular alterations that result in the initiation and progression of the tumorigenic process. Increasing evidence indicates that impaired ability to undergo apoptosis plays an important role in the evolution from androgen-dependent to androgen-independent prostate cancer. In this review, we address recent progress toward the central objectives of understanding the molecular events that contribute to prostate cancer progression. We focus on some key regulatory molecules, including the pro-apoptotic regulators p53, PTEN, caspases and Par-4, and the anti-apoptotic molecules Bcl-2, NF-kappaB and Akt, to discuss their roles in prostate cancer progression and their therapeutic implications in human prostate carcinoma.

AB - Prostate cancer is the most common non-cutaneous malignancy in American men and the second greatest cause of cancer-related death. Development of effective therapeutic modalities for the treatment of this cancer relies heavily on understanding the molecular alterations that result in the initiation and progression of the tumorigenic process. Increasing evidence indicates that impaired ability to undergo apoptosis plays an important role in the evolution from androgen-dependent to androgen-independent prostate cancer. In this review, we address recent progress toward the central objectives of understanding the molecular events that contribute to prostate cancer progression. We focus on some key regulatory molecules, including the pro-apoptotic regulators p53, PTEN, caspases and Par-4, and the anti-apoptotic molecules Bcl-2, NF-kappaB and Akt, to discuss their roles in prostate cancer progression and their therapeutic implications in human prostate carcinoma.

UR - http://www.scopus.com/inward/record.url?scp=16644362550&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=16644362550&partnerID=8YFLogxK

M3 - Article

VL - 14

SP - 23

EP - 34

JO - International Journal of Molecular Medicine

JF - International Journal of Molecular Medicine

SN - 1107-3756

IS - 1

ER -