Apoptotic myocardial degeneration in thrombotic thrombocytopenic purpura

T. N. James, J. B. Alperin

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The objective of this study was to determine whether the known myocardial degeneration in TTP is due to apoptosis. In TTP the heart is often involved, including the cardiac conduction system. Despite many platelet occlusions of small coronary arteries, there is little myocardial necrosis. Why the intermittent clinical episodes begin or end is unknown. Six hearts of patients dying with TTP were examined with routine and immunohistochemical stains. In addition to ventricular and atrial myocardium we examined the cardiac conduction system and coronary chemoreceptor. Numerous small coronary arteries were occluded with platelet thrombi in all these sites, including especially the sinus node, AV node and His bundle. The myocardial degeneration we found was conspicuously devoid of inflammation and the myocytes were relatively intact. These characteristics combined with TUNEL-positivity in the degenerating cells are typical of apoptosis. The focal degeneration in TTP is primarily apoptotic. Because circulating serotonin is carried by platelets and is released during aggregation, and because serotonin can cause a powerful cardiogenic hypertensive chemoreflex, we suggest that such a response may dislodge early platelet aggregations. Lessons from TTP may have special relevance for better understanding of myocardial reperfusion problems associated with angioplasty, thrombolysis and ischemic preconditioning.

Original languageEnglish (US)
Pages (from-to)384-394
Number of pages11
JournalApoptosis
Volume2
Issue number4
StatePublished - 1997

Fingerprint

Thrombotic Thrombocytopenic Purpura
Platelets
Blood Platelets
Serotonin
Coronary Vessels
Agglomeration
Apoptosis
Bundle of His
Atrioventricular Node
Ischemic Preconditioning
Myocardial Reperfusion
Sinoatrial Node
In Situ Nick-End Labeling
Platelet Aggregation
Angioplasty
Muscle Cells
Myocardium
Thrombosis
Necrosis
Coloring Agents

Keywords

  • Apoptosis
  • Cardiac conduction system
  • Cardiogenic hypertensive chemoreflex
  • Myocardial ischemia
  • Platelets
  • Thrombotic thrombocytopenic purpura

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

Cite this

James, T. N., & Alperin, J. B. (1997). Apoptotic myocardial degeneration in thrombotic thrombocytopenic purpura. Apoptosis, 2(4), 384-394.

Apoptotic myocardial degeneration in thrombotic thrombocytopenic purpura. / James, T. N.; Alperin, J. B.

In: Apoptosis, Vol. 2, No. 4, 1997, p. 384-394.

Research output: Contribution to journalArticle

James, TN & Alperin, JB 1997, 'Apoptotic myocardial degeneration in thrombotic thrombocytopenic purpura', Apoptosis, vol. 2, no. 4, pp. 384-394.
James, T. N. ; Alperin, J. B. / Apoptotic myocardial degeneration in thrombotic thrombocytopenic purpura. In: Apoptosis. 1997 ; Vol. 2, No. 4. pp. 384-394.
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