Apoptotic sensitivity of murine IAP-deficient cells

Julie M. Rumble, Mathieu J M Bertrand, Rebecca A. Csomos, Casey Wright, Lori Albert, Tak W. Mak, Philip A. Barker, Colin S. Duckett

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Although numerous studies have implicated the IAPs (inhibitor of apoptosis proteins) in the control of apoptotic cell death, analyses of murine Iap-targeted cells have not revealed significant differences in their susceptibility to apoptosis. In the present study, we show that, under defined conditions, murine cells lacking XIAP (X-linked inhibitor of apoptosis) and c-IAP (cellular IAP) 2, but not c-IAP1, exhibit heightened apoptotic sensitivity to both intrinsic and extrinsic apoptotic stimuli.

Original languageEnglish (US)
Pages (from-to)21-25
Number of pages5
JournalBiochemical Journal
Volume415
Issue number1
DOIs
StatePublished - Oct 1 2008
Externally publishedYes

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Keywords

  • Apoptosis
  • Cellular inhibitor of apoptosis (c-IAP)
  • Inhibitor of apoptosis protein (IAP)
  • Murine fibroblast
  • Tumour necrosis factor (TNF)
  • X-linked inhibitor of apoptosis (XIAP)

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

Rumble, J. M., Bertrand, M. J. M., Csomos, R. A., Wright, C., Albert, L., Mak, T. W., Barker, P. A., & Duckett, C. S. (2008). Apoptotic sensitivity of murine IAP-deficient cells. Biochemical Journal, 415(1), 21-25. https://doi.org/10.1042/BJ20081188