Apoptotic sensitivity of murine IAP-deficient cells

Julie M. Rumble; Mathieu J.M. Bertrand; Rebecca A. Csomos; Casey W. Wright; Lori Albert; Tak W. Mak; Philip A. Barker; Colin S. Duckett

doi:10.1042/BJ20081188

Apoptotic sensitivity of murine IAP-deficient cells

Julie M. Rumble, Mathieu J.M. Bertrand, Rebecca A. Csomos, Casey W. Wright, Lori Albert, Tak W. Mak, Philip A. Barker, Colin S. Duckett

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Although numerous studies have implicated the IAPs (inhibitor of apoptosis proteins) in the control of apoptotic cell death, analyses of murine Iap-targeted cells have not revealed significant differences in their susceptibility to apoptosis. In the present study, we show that, under defined conditions, murine cells lacking XIAP (X-linked inhibitor of apoptosis) and c-IAP (cellular IAP) 2, but not c-IAP1, exhibit heightened apoptotic sensitivity to both intrinsic and extrinsic apoptotic stimuli.

Original language	English (US)
Pages (from-to)	21-25
Number of pages	5
Journal	Biochemical Journal
Volume	415
Issue number	1
DOIs	https://doi.org/10.1042/BJ20081188
State	Published - Oct 1 2008
Externally published	Yes

Keywords

Apoptosis
Cellular inhibitor of apoptosis (c-IAP)
Inhibitor of apoptosis protein (IAP)
Murine fibroblast
Tumour necrosis factor (TNF)
X-linked inhibitor of apoptosis (XIAP)

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1042/BJ20081188

Cite this

@article{93fc6c1e7d7640cd9a9c491498b0cb28,

title = "Apoptotic sensitivity of murine IAP-deficient cells",

abstract = "Although numerous studies have implicated the IAPs (inhibitor of apoptosis proteins) in the control of apoptotic cell death, analyses of murine Iap-targeted cells have not revealed significant differences in their susceptibility to apoptosis. In the present study, we show that, under defined conditions, murine cells lacking XIAP (X-linked inhibitor of apoptosis) and c-IAP (cellular IAP) 2, but not c-IAP1, exhibit heightened apoptotic sensitivity to both intrinsic and extrinsic apoptotic stimuli.",

keywords = "Apoptosis, Cellular inhibitor of apoptosis (c-IAP), Inhibitor of apoptosis protein (IAP), Murine fibroblast, Tumour necrosis factor (TNF), X-linked inhibitor of apoptosis (XIAP)",

author = "Rumble, {Julie M.} and Bertrand, {Mathieu J.M.} and Csomos, {Rebecca A.} and Wright, {Casey W.} and Lori Albert and Mak, {Tak W.} and Barker, {Philip A.} and Duckett, {Colin S.}",

year = "2008",

month = oct,

day = "1",

doi = "10.1042/BJ20081188",

language = "English (US)",

volume = "415",

pages = "21--25",

journal = "Biochemical Journal",

issn = "0264-6021",

publisher = "Portland Press Ltd.",

number = "1",

}

TY - JOUR

T1 - Apoptotic sensitivity of murine IAP-deficient cells

AU - Rumble, Julie M.

AU - Bertrand, Mathieu J.M.

AU - Csomos, Rebecca A.

AU - Wright, Casey W.

AU - Albert, Lori

AU - Mak, Tak W.

AU - Barker, Philip A.

AU - Duckett, Colin S.

PY - 2008/10/1

Y1 - 2008/10/1

N2 - Although numerous studies have implicated the IAPs (inhibitor of apoptosis proteins) in the control of apoptotic cell death, analyses of murine Iap-targeted cells have not revealed significant differences in their susceptibility to apoptosis. In the present study, we show that, under defined conditions, murine cells lacking XIAP (X-linked inhibitor of apoptosis) and c-IAP (cellular IAP) 2, but not c-IAP1, exhibit heightened apoptotic sensitivity to both intrinsic and extrinsic apoptotic stimuli.

AB - Although numerous studies have implicated the IAPs (inhibitor of apoptosis proteins) in the control of apoptotic cell death, analyses of murine Iap-targeted cells have not revealed significant differences in their susceptibility to apoptosis. In the present study, we show that, under defined conditions, murine cells lacking XIAP (X-linked inhibitor of apoptosis) and c-IAP (cellular IAP) 2, but not c-IAP1, exhibit heightened apoptotic sensitivity to both intrinsic and extrinsic apoptotic stimuli.

KW - Apoptosis

KW - Cellular inhibitor of apoptosis (c-IAP)

KW - Inhibitor of apoptosis protein (IAP)

KW - Murine fibroblast

KW - Tumour necrosis factor (TNF)

KW - X-linked inhibitor of apoptosis (XIAP)

UR - http://www.scopus.com/inward/record.url?scp=53149121298&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=53149121298&partnerID=8YFLogxK

U2 - 10.1042/BJ20081188

DO - 10.1042/BJ20081188

M3 - Article

C2 - 18684108

AN - SCOPUS:53149121298

SN - 0264-6021

VL - 415

SP - 21

EP - 25

JO - Biochemical Journal

JF - Biochemical Journal

IS - 1

ER -

Apoptotic sensitivity of murine IAP-deficient cells

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this