Application of kinetic principles to intravenous fluid therapy

Donald S. Prough, Kirk I. Brauer

Research output: Contribution to journalReview article

5 Scopus citations


The clinical understanding of changes in plasma volume and other body water compartments induced by infusion of intravenous fluids has been poorly quantified. Recently, investigators have studied the effects of intravenous fluids on volume expansion using mathematic techniques similar to those used for pharmacokinetic analysis of drugs. Combining these techniques with traditional concepts regarding perioperative fluid therapy promises to increase the precision with which fluids are given before, during, and after surgery.

Original languageEnglish (US)
Pages (from-to)419-433
Number of pages15
JournalProblems in Anesthesia
Issue number4
StatePublished - Oct 1 1999


ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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