Application of the enzyme linked immunosorbent assay (ELISA) for the serodiagnosis of Schistosoma mansoni infections in St. Lucia

Moira L. McLaren, E. G. Long, R. W. Goodgame, Jane E. Lillywhite

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

As part of our search for a serodiagnostic assay to replace the expensive and tedious stool examination in the diagnosis of Schistosoma mansoni infection, we have studied the sensitivity, specificity and quantitative features of an enzyme linked immunoassay (ELISA) using crude S. mansoni egg antigen preparation. Results of studies carried out in both London and St. Lucia indicate that the assay can give useful serodiagnostic information ranging from 82 to 99·5% sensitivity, depending on level of infection intensity and method of blood collection and 100% specificity in St. Lucian/St. Vincent populations. The St. Lucia study also showed that the assay could be operated in a qualitative form in an endemic area.

Original languageEnglish (US)
Pages (from-to)636-639
Number of pages4
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume73
Issue number6
DOIs
StatePublished - 1979
Externally publishedYes

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Saint Lucia
Schistosomiasis mansoni
Serologic Tests
Enzyme-Linked Immunosorbent Assay
Schistosoma mansoni
Immunoenzyme Techniques
Ovum
Antigens
Sensitivity and Specificity
Infection
Population

ASJC Scopus subject areas

  • Parasitology
  • Medicine(all)

Cite this

Application of the enzyme linked immunosorbent assay (ELISA) for the serodiagnosis of Schistosoma mansoni infections in St. Lucia. / McLaren, Moira L.; Long, E. G.; Goodgame, R. W.; Lillywhite, Jane E.

In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 73, No. 6, 1979, p. 636-639.

Research output: Contribution to journalArticle

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