Application of vitamin D and derivatives in hematological malignancies

Minji Kim, Leonardo Mirandola, Apurva Pandey, Diane D. Nguyen, Marjorie R. Jenkins, Meryem Turcel, Everardo Cobos, Maurizio Chiriva-Internati

Research output: Contribution to journalShort survey

19 Scopus citations

Abstract

The role of vitamin D in the inhibition of malignant cell proliferation in hematological malignancies is indicative of its future use in cancer therapy. An understanding of the biochemical mechanism by which vitamin D and its derivatives exert their effects will prove to be useful in the development of clinically applicable therapies involving vitamin D. While the use of vitamin D in clinical trials against acute myeloid leukemia and myelodysplastic syndrome has been met with few successes thus far,. in vitro and. in vivo studies as well as epidemiological correlations between vitamin D deficiency and cancer have implicated the great potential of the use of vitamin D derivatives in effective therapies against neoplastic diseases. For these reasons, a focus on current understanding of role of vitamin D and derivatives in hematologic malignancies is relevant and the goal for this review.

Original languageEnglish (US)
Pages (from-to)8-22
Number of pages15
JournalCancer Letters
Volume319
Issue number1
DOIs
StatePublished - Jun 1 2012

Keywords

  • Clinical trials
  • Hematological malignancies
  • Intracellular kinases
  • Multiple myeloma
  • Vitamin D

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Kim, M., Mirandola, L., Pandey, A., Nguyen, D. D., Jenkins, M. R., Turcel, M., Cobos, E., & Chiriva-Internati, M. (2012). Application of vitamin D and derivatives in hematological malignancies. Cancer Letters, 319(1), 8-22. https://doi.org/10.1016/j.canlet.2011.10.026