Abstract
The role of vitamin D in the inhibition of malignant cell proliferation in hematological malignancies is indicative of its future use in cancer therapy. An understanding of the biochemical mechanism by which vitamin D and its derivatives exert their effects will prove to be useful in the development of clinically applicable therapies involving vitamin D. While the use of vitamin D in clinical trials against acute myeloid leukemia and myelodysplastic syndrome has been met with few successes thus far,. in vitro and. in vivo studies as well as epidemiological correlations between vitamin D deficiency and cancer have implicated the great potential of the use of vitamin D derivatives in effective therapies against neoplastic diseases. For these reasons, a focus on current understanding of role of vitamin D and derivatives in hematologic malignancies is relevant and the goal for this review.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8-22 |
| Number of pages | 15 |
| Journal | Cancer Letters |
| Volume | 319 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jun 1 2012 |
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Keywords
- Clinical trials
- Hematological malignancies
- Intracellular kinases
- Multiple myeloma
- Vitamin D
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Application of vitamin D and derivatives in hematological malignancies. / Kim, Minji; Mirandola, Leonardo; Pandey, Apurva; Nguyen, Diane D.; Jenkins, Marjorie R.; Turcel, Meryem; Cobos, Everardo; Chiriva-Internati, Maurizio.
In: Cancer Letters, Vol. 319, No. 1, 01.06.2012, p. 8-22.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Application of vitamin D and derivatives in hematological malignancies
AU - Kim, Minji
AU - Mirandola, Leonardo
AU - Pandey, Apurva
AU - Nguyen, Diane D.
AU - Jenkins, Marjorie R.
AU - Turcel, Meryem
AU - Cobos, Everardo
AU - Chiriva-Internati, Maurizio
PY - 2012/6/1
Y1 - 2012/6/1
N2 - The role of vitamin D in the inhibition of malignant cell proliferation in hematological malignancies is indicative of its future use in cancer therapy. An understanding of the biochemical mechanism by which vitamin D and its derivatives exert their effects will prove to be useful in the development of clinically applicable therapies involving vitamin D. While the use of vitamin D in clinical trials against acute myeloid leukemia and myelodysplastic syndrome has been met with few successes thus far,. in vitro and. in vivo studies as well as epidemiological correlations between vitamin D deficiency and cancer have implicated the great potential of the use of vitamin D derivatives in effective therapies against neoplastic diseases. For these reasons, a focus on current understanding of role of vitamin D and derivatives in hematologic malignancies is relevant and the goal for this review.
AB - The role of vitamin D in the inhibition of malignant cell proliferation in hematological malignancies is indicative of its future use in cancer therapy. An understanding of the biochemical mechanism by which vitamin D and its derivatives exert their effects will prove to be useful in the development of clinically applicable therapies involving vitamin D. While the use of vitamin D in clinical trials against acute myeloid leukemia and myelodysplastic syndrome has been met with few successes thus far,. in vitro and. in vivo studies as well as epidemiological correlations between vitamin D deficiency and cancer have implicated the great potential of the use of vitamin D derivatives in effective therapies against neoplastic diseases. For these reasons, a focus on current understanding of role of vitamin D and derivatives in hematologic malignancies is relevant and the goal for this review.
KW - Clinical trials
KW - Hematological malignancies
KW - Intracellular kinases
KW - Multiple myeloma
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=84862809395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862809395&partnerID=8YFLogxK
U2 - 10.1016/j.canlet.2011.10.026
DO - 10.1016/j.canlet.2011.10.026
M3 - Article
C2 - 22193723
AN - SCOPUS:84862809395
VL - 319
SP - 8
EP - 22
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 1
ER -