Applications of MALDI-MSI to pharmaceutical research

Brendan Prideaux, Dieter Staab, Markus Stoeckli

Research output: Chapter in Book/Report/Conference proceedingChapter

24 Citations (Scopus)

Abstract

MALDI-MSI has been demonstrated to be a suitable technique in pharmaceutical research for providing information of the distribution of low molecular weight compounds such as drugs and their metabolites within whole-body tissue sections. Important ADME information can be determined by MALDI-MSI analysis of the distribution of drugs and metabolites in whole-body tissue sections taken from animals killed at a range of time points postdose. In this example we applied MALDI-MSI to the localization of a compound and its primary metabolite in whole-body mouse sections.

Original languageEnglish (US)
Title of host publicationMass Spectrometry Imaging
Subtitle of host publicationPrinciples and Protocols
EditorsStanislav Rubakhin, Jonathan Sweedler
Pages405-413
Number of pages9
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume656
ISSN (Print)1064-3745

Fingerprint

Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Information Dissemination
Pharmaceutical Preparations
Molecular Weight
N-methylsuccinimide
Pharmaceutical Research

Keywords

  • drug and metabolite imaging
  • MALDI-MSI
  • whole-body tissue imaging

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Prideaux, B., Staab, D., & Stoeckli, M. (2010). Applications of MALDI-MSI to pharmaceutical research. In S. Rubakhin, & J. Sweedler (Eds.), Mass Spectrometry Imaging: Principles and Protocols (pp. 405-413). (Methods in Molecular Biology; Vol. 656). https://doi.org/10.1007/978-1-60761-746-4_23

Applications of MALDI-MSI to pharmaceutical research. / Prideaux, Brendan; Staab, Dieter; Stoeckli, Markus.

Mass Spectrometry Imaging: Principles and Protocols. ed. / Stanislav Rubakhin; Jonathan Sweedler. 2010. p. 405-413 (Methods in Molecular Biology; Vol. 656).

Research output: Chapter in Book/Report/Conference proceedingChapter

Prideaux, B, Staab, D & Stoeckli, M 2010, Applications of MALDI-MSI to pharmaceutical research. in S Rubakhin & J Sweedler (eds), Mass Spectrometry Imaging: Principles and Protocols. Methods in Molecular Biology, vol. 656, pp. 405-413. https://doi.org/10.1007/978-1-60761-746-4_23
Prideaux B, Staab D, Stoeckli M. Applications of MALDI-MSI to pharmaceutical research. In Rubakhin S, Sweedler J, editors, Mass Spectrometry Imaging: Principles and Protocols. 2010. p. 405-413. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-60761-746-4_23
Prideaux, Brendan ; Staab, Dieter ; Stoeckli, Markus. / Applications of MALDI-MSI to pharmaceutical research. Mass Spectrometry Imaging: Principles and Protocols. editor / Stanislav Rubakhin ; Jonathan Sweedler. 2010. pp. 405-413 (Methods in Molecular Biology).
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