Appreciating force and shape-the rise of mechanotransduction in cell biology

Thomas Iskratsch, Haguy Wolfenson, Michael Sheetz

Research output: Contribution to journalReview article

265 Scopus citations

Abstract

Although the shapes of organisms are encoded in their genome, the developmental processes that lead to the final form of vertebrates involve a constant feedback between dynamic mechanical forces, and cell growth and motility. Mechanobiology has emerged as a discipline dedicated to the study of the effects of mechanical forces and geometry on cell growth and motility-for example, during cell-matrix adhesion development-through the signalling process of mechanotransduction.

Original languageEnglish (US)
Pages (from-to)825-833
Number of pages9
JournalNature Reviews Molecular Cell Biology
Volume15
Issue number12
DOIs
StatePublished - Dec 11 2014
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this