Aptamers containing thymidine 3'-O-phosphorodithioates: Synthesis and binding to nuclear factor-κB

Xianbin Yang; Susan Fennewald; Bruce A. Luxon; Judy Aronson; Norbert K. Herzog; David G. Gorenstein

doi:10.1016/S0960-894X(99)00600-9

Aptamers containing thymidine 3'-O-phosphorodithioates: Synthesis and binding to nuclear factor-κB

Xianbin Yang, Susan Fennewald, Bruce A. Luxon, Judy Aronson, Norbert K. Herzog, David G. Gorenstein

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46 Scopus citations

Abstract

Aptamers targeting NF-κB containing thymidine 3'-O-phosphorodithioates in selected positions of an oligonucleotide duplex were synthesized. Binding affinities to NF-κB varied with the number and positions of the dithioate backbone substitutions. One of the aptamers showed specific binding to a single NF-κB dimer in cell culture extracts.

Original language	English (US)
Pages (from-to)	3357-3362
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	23
DOIs	https://doi.org/10.1016/S0960-894X(99)00600-9
State	Published - Dec 6 1999

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(99)00600-9

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abstract = "Aptamers targeting NF-κB containing thymidine 3'-O-phosphorodithioates in selected positions of an oligonucleotide duplex were synthesized. Binding affinities to NF-κB varied with the number and positions of the dithioate backbone substitutions. One of the aptamers showed specific binding to a single NF-κB dimer in cell culture extracts.",

author = "Xianbin Yang and Susan Fennewald and Luxon, {Bruce A.} and Judy Aronson and Herzog, {Norbert K.} and Gorenstein, {David G.}",

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T2 - Synthesis and binding to nuclear factor-κB

AU - Yang, Xianbin

AU - Fennewald, Susan

AU - Luxon, Bruce A.

AU - Aronson, Judy

AU - Herzog, Norbert K.

AU - Gorenstein, David G.

PY - 1999/12/6

Y1 - 1999/12/6

N2 - Aptamers targeting NF-κB containing thymidine 3'-O-phosphorodithioates in selected positions of an oligonucleotide duplex were synthesized. Binding affinities to NF-κB varied with the number and positions of the dithioate backbone substitutions. One of the aptamers showed specific binding to a single NF-κB dimer in cell culture extracts.

AB - Aptamers targeting NF-κB containing thymidine 3'-O-phosphorodithioates in selected positions of an oligonucleotide duplex were synthesized. Binding affinities to NF-κB varied with the number and positions of the dithioate backbone substitutions. One of the aptamers showed specific binding to a single NF-κB dimer in cell culture extracts.

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Aptamers containing thymidine 3'-O-phosphorodithioates: Synthesis and binding to nuclear factor-κB

Abstract

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