Aptamers containing thymidine 3'-O-phosphorodithioates: Synthesis and binding to nuclear factor-κB

Xianbin Yang, Susan Fennewald, Bruce A. Luxon, Judith Aronson, Norbert K. Herzog, David G. Gorenstein

41 Scopus citations

Abstract

Aptamers targeting NF-κB containing thymidine 3'-O-phosphorodithioates in selected positions of an oligonucleotide duplex were synthesized. Binding affinities to NF-κB varied with the number and positions of the dithioate backbone substitutions. One of the aptamers showed specific binding to a single NF-κB dimer in cell culture extracts.

Original languageEnglish (US)
Pages (from-to)3357-3362
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number23
StatePublished - Dec 6 1999

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Yang, X., Fennewald, S., Luxon, B. A., Aronson, J., Herzog, N. K., & Gorenstein, D. G. (1999). Aptamers containing thymidine 3'-O-phosphorodithioates: Synthesis and binding to nuclear factor-κB. Bioorganic and Medicinal Chemistry Letters, 9(23), 3357-3362.