Arachidonic acid inhibits 5-lipoxygenase in human T cells

Durgaprasadarao Atluru, Elias A. Lianos, James S. Goodwin

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The data on whether T cells produce leukotrienes or other 5-lipoxygenase metabolites of arachidonic acid is conflicting. We report that exogenous arachidonic acid added to phytohemagglutin-stimulated human T cells profoundly inhibits leukotriene B4 production, with 90% inhibition caused by 10-6 M arachidonic acid. The 12-and 15-lipoxygenase pathways were also inhibited by arachidonic acid. Recent reports that human T cells produce no 5-lipoxygenase metabolites of arachidonic acid might be explained by the fact that the studies used ≥ 10-5M arachidonic acid in the incubation media.

Original languageEnglish (US)
Pages (from-to)670-676
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume135
Issue number2
DOIs
StatePublished - Mar 13 1986
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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