Araguari virus, a new member of the family Orthomyxoviridae: Serologic, ultrastructural, and molecular characterization

Eliana V. Pinto Da Silva, Amelia P A Travassos Da Rosa, Márcio R T Nunes, José A P Diniz, Robert B. Tesh, Ana C R Cruz, Conceição M A Vieira, Pedro F C Vasconcelos

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

This paper reports the results of serologic, structural, biochemical, and genetic studies indicating that Araguari virus, a previously unassigned viral agent, is a member of the family Orthomyxoviridae and genus Thogotovirus. Araguari virus has six RNA fragments; biologically, it shares several properties with other viruses in the family Orthomyxoviridae. Nucleotide sequencing of the RNA segments 4 (glycoprotein) and 5 (nucleoprotein) of Araguari virus aligned with the orthomyxoviruses, showing the closest relationship with Thogoto virus (sequence similarity = 61.9% and 69.1%, respectively, for glycoprotein and nucleoprotein), but also sharing a more distant similarity with Dhori and Influenza C viruses, especially for the glycoprotein gene. Based on these results, we propose that Araguari virus should be assigned as a new member of the family Orthomyxoviridae and genus Thogotovirus.

Original languageEnglish (US)
Pages (from-to)1050-1058
Number of pages9
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume73
Issue number6
StatePublished - Dec 2005

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Thogotovirus
Orthomyxoviridae
Viruses
Glycoproteins
Nucleoproteins
Influenzavirus C
RNA Sequence Analysis
Molecular Biology
Nucleotides
RNA
Genes

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Pinto Da Silva, E. V., Travassos Da Rosa, A. P. A., Nunes, M. R. T., Diniz, J. A. P., Tesh, R. B., Cruz, A. C. R., ... Vasconcelos, P. F. C. (2005). Araguari virus, a new member of the family Orthomyxoviridae: Serologic, ultrastructural, and molecular characterization. American Journal of Tropical Medicine and Hygiene, 73(6), 1050-1058.

Araguari virus, a new member of the family Orthomyxoviridae : Serologic, ultrastructural, and molecular characterization. / Pinto Da Silva, Eliana V.; Travassos Da Rosa, Amelia P A; Nunes, Márcio R T; Diniz, José A P; Tesh, Robert B.; Cruz, Ana C R; Vieira, Conceição M A; Vasconcelos, Pedro F C.

In: American Journal of Tropical Medicine and Hygiene, Vol. 73, No. 6, 12.2005, p. 1050-1058.

Research output: Contribution to journalArticle

Pinto Da Silva, EV, Travassos Da Rosa, APA, Nunes, MRT, Diniz, JAP, Tesh, RB, Cruz, ACR, Vieira, CMA & Vasconcelos, PFC 2005, 'Araguari virus, a new member of the family Orthomyxoviridae: Serologic, ultrastructural, and molecular characterization', American Journal of Tropical Medicine and Hygiene, vol. 73, no. 6, pp. 1050-1058.
Pinto Da Silva EV, Travassos Da Rosa APA, Nunes MRT, Diniz JAP, Tesh RB, Cruz ACR et al. Araguari virus, a new member of the family Orthomyxoviridae: Serologic, ultrastructural, and molecular characterization. American Journal of Tropical Medicine and Hygiene. 2005 Dec;73(6):1050-1058.
Pinto Da Silva, Eliana V. ; Travassos Da Rosa, Amelia P A ; Nunes, Márcio R T ; Diniz, José A P ; Tesh, Robert B. ; Cruz, Ana C R ; Vieira, Conceição M A ; Vasconcelos, Pedro F C. / Araguari virus, a new member of the family Orthomyxoviridae : Serologic, ultrastructural, and molecular characterization. In: American Journal of Tropical Medicine and Hygiene. 2005 ; Vol. 73, No. 6. pp. 1050-1058.
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