Arbovirus Evolution

Kathryn A. Hanley, Scott Weaver

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Citations (Scopus)

Abstract

Arboviruses (ar thropodborne viruses), though taxonomically diverse, share a cycle of transmission between vertebrate hosts and arthropod vectors. All but one arbovirus species belong to one of five families of RNA viruses, suggesting that the high mutation frequencies of RNA genomes may be a prerequisite for entry into a cycle of alternating replication in the very different environments represented by vertebrate and invertebrate animals. Arboviruses such as dengue, yellow fever, and Venezuelan equine encephalitis viruses pose significant, recognized threats to human and animal health. Moreover, the potential for new arboviruses to emerge from enzootic cycles to cause disease in humans and domestic animals, or for recognized arboviruses to spread into new geographic areas, is already high and may be exacerbated by ongoing changes in human demography and global climate. Thus it is critical to understand the forces that shape the evolution of arboviruses in order to better predict their emergence and to control their spread. In this chapter we review existing scholarship on the origin, diversification and evolution of host and vector use of arboviruses, with a focus on the two best-studied groups: the vector-borne alphaviviruses and flaviviruses. Specifically, we review the contribution of phylogenetic analysis to current understanding of arbovirus evolution and epidemiology, we evaluate the role of recombination and reassortment in the origin of new arboviruses, and we examine the mechanisms of arbovirus emergence and geographic spread. In addition, we discuss the impact of cycles of alternating replication in vertebrate hosts and vectors on the rates and patterns of arbovirus evolution and the selection imposed by alternating transmission cycles on specificarbovirus phenotypes. Finally we consider the challenges that arbovirus evolution may pose to the deployment of existing and novel measures for disease control.

Original languageEnglish (US)
Title of host publicationOrigin and Evolution of Viruses
PublisherElsevier Ltd
Pages351-391
Number of pages41
ISBN (Print)9780123741530
DOIs
StatePublished - 2008

Fingerprint

Arboviruses
Viruses
Vertebrates
Arthropod Vectors
Venezuelan Equine Encephalitis Viruses
Yellow Fever
Flavivirus
Dengue
RNA Viruses
Domestic Animals
Mutation Rate
Invertebrates
Climate
Genetic Recombination
Epidemiology
Demography
Genome
RNA
Phenotype
Health

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Hanley, K. A., & Weaver, S. (2008). Arbovirus Evolution. In Origin and Evolution of Viruses (pp. 351-391). Elsevier Ltd. https://doi.org/10.1016/B978-0-12-374153-0.00016-3

Arbovirus Evolution. / Hanley, Kathryn A.; Weaver, Scott.

Origin and Evolution of Viruses. Elsevier Ltd, 2008. p. 351-391.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hanley, KA & Weaver, S 2008, Arbovirus Evolution. in Origin and Evolution of Viruses. Elsevier Ltd, pp. 351-391. https://doi.org/10.1016/B978-0-12-374153-0.00016-3
Hanley KA, Weaver S. Arbovirus Evolution. In Origin and Evolution of Viruses. Elsevier Ltd. 2008. p. 351-391 https://doi.org/10.1016/B978-0-12-374153-0.00016-3
Hanley, Kathryn A. ; Weaver, Scott. / Arbovirus Evolution. Origin and Evolution of Viruses. Elsevier Ltd, 2008. pp. 351-391
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