Are fetal microchimerism and circulating fetal extracellular vesicles important links between spontaneous preterm delivery and maternal cardiovascular disease risk?

Elizabeth A. Bonney, Ryan C.V. Lintao, Carolyn M. Zelop, Ananth Kumar Kammala, Ramkumar Menon

Research output: Contribution to journalArticlepeer-review

Abstract

Trafficking and persistence of fetal microchimeric cells (fMCs) and circulating extracellular vesicles (EVs) have been observed in animals and humans, but their consequences in the maternal body and their mechanistic contributions to maternal physiology and pathophysiology are not yet fully defined. Fetal cells and EVs may help remodel maternal organs after pregnancy-associated changes, but the cell types and EV cargos reaching the mother in preterm pregnancies after exposure to various risk factors can be distinct from term pregnancies. As preterm delivery-associated maternal complications are rising, revisiting this topic and formulating scientific questions for future research to reduce the risk of maternal morbidities are timely. Epidemiological studies report maternal cardiovascular risk as one of the major complications after preterm delivery. This paper suggests a potential link between fMCs and circulating EVs and adverse maternal cardiovascular outcomes post-pregnancies, the underlying mechanisms, consequences, and methods for and how this link might be assessed.

Original languageEnglish (US)
Article number2300170
JournalBioEssays
Volume46
Issue number4
DOIs
StatePublished - Apr 2024
Externally publishedYes

Keywords

  • cardiomyocyte function
  • cardiovascular risk
  • fetal microchimerism
  • maternal morbidity
  • pregnancy
  • women

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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