Are increased Foxp3+ regulatory T cells responsible for immunosuppression during HTLV-1 infection? Case reports and review of the literature.

Nicolas Barros, Fernando Woll, Luis Watanabe, Martin Montes

Research output: Contribution to journalArticle

Abstract

Research of human T lymphotropic virus type I (HTLV-1)-associated diseases is mostly focused on inflammatory and lymphoproliferative disorders. However, the immunosuppressive consequences of HTLV-1 infection are frequently ignored. In developing countries where exposure to parasitic and other tropical diseases is frequent, the burden of disease is significantly increased by opportunistic infections. Regulatory T cells (Tregs) are a CD4 T-cell subset capable of suppressing effector responses. During HTLV-1 infection, CD4+Foxp3+ cells are increased in HTLV-1-associated leukaemia/lymphoma (ATLL) as well as in non-leukaemic presentations. However, controversy exists regarding the actual regulatory function of these cells. In this report, we present two cases of HTLV-1 ATLL complicated by parasitic organisms and we provide a brief review of the literature regarding FoxP3+ regulatory T cells and their role as a possible mechanism for the immunosuppressive manifestations that take place during HTLV-1 infection.

Original languageEnglish (US)
JournalBMJ Case Reports
Volume2012
StatePublished - 2012
Externally publishedYes

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Deltaretrovirus Infections
Human T-lymphotropic virus 1
Regulatory T-Lymphocytes
Immunosuppression
Adult T Cell Leukemia Lymphoma
Immunosuppressive Agents
Lymphoproliferative Disorders
Opportunistic Infections
T-Lymphocyte Subsets
Developing Countries
Viruses
Research

ASJC Scopus subject areas

  • Medicine(all)

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Are increased Foxp3+ regulatory T cells responsible for immunosuppression during HTLV-1 infection? Case reports and review of the literature. / Barros, Nicolas; Woll, Fernando; Watanabe, Luis; Montes, Martin.

In: BMJ Case Reports, Vol. 2012, 2012.

Research output: Contribution to journalArticle

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