Are interatrial band myocytes maximally hypertrophied in normal canine hearts?

Paul C. Dolber, Robert P. Bauman, Judith C. Rembert, Joseph C. Greenfield

    Research output: Contribution to journalArticle

    1 Scopus citations

    Abstract

    In canine right atrial hypertrophy, the cross-sectional area (A(xs)) of right atrial myocytes increases, whereas the A(xs) of the broader interatrial band myocytes does not. In the current study, myocyte reconstructions showed that right atrial myocyte length increased in proportion to A(xs) in right atrial hypertrophy. On the other hand, mean interatrial band myocyte length in both normal and right atrial hypertrophy dogs was roughly inversely proportional to mean A(xs), as expected if interatrial band myocyte volume was constant. Plotting mean A(xs) vs. myocyte length for individual interatrial band myocytes revealed a distribution whose border defined a maximal volume curve; many myocytes were well beneath that curve. Mononuclear myocytes (generally diploid) were limited by a 65,000-μm3 curve, which many binuclear myocytes (generally tetraploid) surpassed; myocyte ploidy thus constrained myocyte volume. However, because many mononuclear and binuclear myocytes had lower volumes, their failure to hypertrophy cannot be attributed to attainment of the maximal volume possible for their ploidy.

    Original languageEnglish (US)
    Pages (from-to)H1225-H1235
    JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
    Volume275
    Issue number4 44-4
    StatePublished - Nov 9 1998

    Keywords

    • Atrium
    • Cardiac muscle
    • Hypertrophy
    • Myocyte size
    • Ploidy

    ASJC Scopus subject areas

    • Physiology
    • Cardiology and Cardiovascular Medicine
    • Physiology (medical)

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  • Cite this

    Dolber, P. C., Bauman, R. P., Rembert, J. C., & Greenfield, J. C. (1998). Are interatrial band myocytes maximally hypertrophied in normal canine hearts? American Journal of Physiology - Heart and Circulatory Physiology, 275(4 44-4), H1225-H1235.