Are prostaglandins proinflammatory, antiinflammatory, both or neither?

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Research on the role of prostaglandins (PG) in inflammation has been divided along 2 lines of inquiry. One supposes that PG are proinflammatory, explaining why nonsteroidal antiinflammatory drugs (NSAID), which prevent conversion of arachidonic acid to stable PG through cyclooxygenase inhibition, exert their antiinflammatory effects. The other supposes that PG are antiinflammatory, explaining the reductions in inflammation produced by these substances in various experimental models of arthritis. A number of proinflammatory actions of PG have been identified, including vasodilatation and hyperalgesia. However, these activities are relatively modest and do not appear to account for the antiinflammatory effects of NSAID; indeed, mechanisms for these effects that do not depend on cyclooxygenase inhibition have been advanced. A number of potential mechanisms for antiinflammatory effects of PGE have been identified, including inhibition of neutrophil activation, O2 release and leukotriene B4 and cytokine production. It is likely that the availability of orally active PGE analogs will permit study leading to an integrated understanding of PG activity and an answer to the question whether such agents will prove useful in the treatment of chronic inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)26-29
Number of pages4
JournalJournal of Rheumatology
Volume18
Issue numberSUPPL. 28
StatePublished - 1991
Externally publishedYes

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Prostaglandins
Anti-Inflammatory Agents
Prostaglandin-Endoperoxide Synthases
Prostaglandins E
Inflammation
Neutrophil Activation
Experimental Arthritis
Leukotriene B4
Hyperalgesia
Arachidonic Acid
Vasodilation
Pharmaceutical Preparations
Chronic Disease
Theoretical Models
Cytokines
Research

Keywords

  • Antiinflammatory effects
  • NSAID
  • Proinflammatory effects
  • Prostaglandin E analogs
  • Prostaglandins

ASJC Scopus subject areas

  • Immunology
  • Rheumatology
  • Medicine(all)

Cite this

Are prostaglandins proinflammatory, antiinflammatory, both or neither? / Goodwin, James.

In: Journal of Rheumatology, Vol. 18, No. SUPPL. 28, 1991, p. 26-29.

Research output: Contribution to journalArticle

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