Are Visceral Proteins Valid Markers for Nutritional Status in the Burn Intensive Care Unit?

Beth A. Shields, Heather F. Pidcoke, Kevin K. Chung, Charles E. Wade, Wenjun Z. Martini, Evan M. Renz, Steven Wolf

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The aim of this study was to determine whether visceral protein levels increase under positive nitrogen balance during times of decrease in acute-phase reactant levels in patients with burn injury. This was a post hoc analysis of a prospective, interventional study approved by the local institutional review board. A total of 10 subjects between the ages of 18 and 72 with ≥20% total body surface area burn were enrolled over a 14-month period. Data were collected for five subjects (average age of 28 ± 8 years and total body surface area burn of 69 ± 15%) who met the inclusion criteria. Changes in visceral protein levels were examined along with nitrogen balance and acute-phase reactants when the subjects were on enteral nutrition, and the proteins were not examined during times of acute kidney injury. Descriptive statistics were performed, and linear regression was used to analyze the association of visceral proteins and nitrogen balance during times that acute-phase reactant levels were decreasing. The subjects received an average of 3044 ± 1613 kcal/day (39 ± 20 kcal/kg), meeting 72% of caloric goals and achieving positive nitrogen balance during 68% of the 40 weekly measurements, with 174 ± 85 g of protein intake per day (2.2 ± 1.1 g/kg). There was a weak relationship between nitrogen balance and changes in visceral protein levels during times that the acute-phase reactant levels were decreasing (P >.05). Visceral proteins were found to be poor markers of nutritional status. This study is unique because the subjects were able to achieve positive nitrogen balance despite severe burns.

Original languageEnglish (US)
Pages (from-to)375-380
Number of pages6
JournalJournal of Burn Care and Research
Volume36
Issue number3
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Nutritional Status
Intensive Care Units
Nitrogen
Acute-Phase Proteins
Proteins
Body Surface Area
Research Ethics Committees
Enteral Nutrition
Burns
Acute Kidney Injury
Linear Models
Prospective Studies
Wounds and Injuries

ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Rehabilitation

Cite this

Are Visceral Proteins Valid Markers for Nutritional Status in the Burn Intensive Care Unit? / Shields, Beth A.; Pidcoke, Heather F.; Chung, Kevin K.; Wade, Charles E.; Martini, Wenjun Z.; Renz, Evan M.; Wolf, Steven.

In: Journal of Burn Care and Research, Vol. 36, No. 3, 01.01.2015, p. 375-380.

Research output: Contribution to journalArticle

Shields, Beth A. ; Pidcoke, Heather F. ; Chung, Kevin K. ; Wade, Charles E. ; Martini, Wenjun Z. ; Renz, Evan M. ; Wolf, Steven. / Are Visceral Proteins Valid Markers for Nutritional Status in the Burn Intensive Care Unit?. In: Journal of Burn Care and Research. 2015 ; Vol. 36, No. 3. pp. 375-380.
@article{4540d6c9b1e64ae89ce1e630dafdc7c3,
title = "Are Visceral Proteins Valid Markers for Nutritional Status in the Burn Intensive Care Unit?",
abstract = "The aim of this study was to determine whether visceral protein levels increase under positive nitrogen balance during times of decrease in acute-phase reactant levels in patients with burn injury. This was a post hoc analysis of a prospective, interventional study approved by the local institutional review board. A total of 10 subjects between the ages of 18 and 72 with ≥20{\%} total body surface area burn were enrolled over a 14-month period. Data were collected for five subjects (average age of 28 ± 8 years and total body surface area burn of 69 ± 15{\%}) who met the inclusion criteria. Changes in visceral protein levels were examined along with nitrogen balance and acute-phase reactants when the subjects were on enteral nutrition, and the proteins were not examined during times of acute kidney injury. Descriptive statistics were performed, and linear regression was used to analyze the association of visceral proteins and nitrogen balance during times that acute-phase reactant levels were decreasing. The subjects received an average of 3044 ± 1613 kcal/day (39 ± 20 kcal/kg), meeting 72{\%} of caloric goals and achieving positive nitrogen balance during 68{\%} of the 40 weekly measurements, with 174 ± 85 g of protein intake per day (2.2 ± 1.1 g/kg). There was a weak relationship between nitrogen balance and changes in visceral protein levels during times that the acute-phase reactant levels were decreasing (P >.05). Visceral proteins were found to be poor markers of nutritional status. This study is unique because the subjects were able to achieve positive nitrogen balance despite severe burns.",
author = "Shields, {Beth A.} and Pidcoke, {Heather F.} and Chung, {Kevin K.} and Wade, {Charles E.} and Martini, {Wenjun Z.} and Renz, {Evan M.} and Steven Wolf",
year = "2015",
month = "1",
day = "1",
doi = "10.1097/BCR.0000000000000101",
language = "English (US)",
volume = "36",
pages = "375--380",
journal = "Journal of Burn Care and Research",
issn = "1559-047X",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Are Visceral Proteins Valid Markers for Nutritional Status in the Burn Intensive Care Unit?

AU - Shields, Beth A.

AU - Pidcoke, Heather F.

AU - Chung, Kevin K.

AU - Wade, Charles E.

AU - Martini, Wenjun Z.

AU - Renz, Evan M.

AU - Wolf, Steven

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The aim of this study was to determine whether visceral protein levels increase under positive nitrogen balance during times of decrease in acute-phase reactant levels in patients with burn injury. This was a post hoc analysis of a prospective, interventional study approved by the local institutional review board. A total of 10 subjects between the ages of 18 and 72 with ≥20% total body surface area burn were enrolled over a 14-month period. Data were collected for five subjects (average age of 28 ± 8 years and total body surface area burn of 69 ± 15%) who met the inclusion criteria. Changes in visceral protein levels were examined along with nitrogen balance and acute-phase reactants when the subjects were on enteral nutrition, and the proteins were not examined during times of acute kidney injury. Descriptive statistics were performed, and linear regression was used to analyze the association of visceral proteins and nitrogen balance during times that acute-phase reactant levels were decreasing. The subjects received an average of 3044 ± 1613 kcal/day (39 ± 20 kcal/kg), meeting 72% of caloric goals and achieving positive nitrogen balance during 68% of the 40 weekly measurements, with 174 ± 85 g of protein intake per day (2.2 ± 1.1 g/kg). There was a weak relationship between nitrogen balance and changes in visceral protein levels during times that the acute-phase reactant levels were decreasing (P >.05). Visceral proteins were found to be poor markers of nutritional status. This study is unique because the subjects were able to achieve positive nitrogen balance despite severe burns.

AB - The aim of this study was to determine whether visceral protein levels increase under positive nitrogen balance during times of decrease in acute-phase reactant levels in patients with burn injury. This was a post hoc analysis of a prospective, interventional study approved by the local institutional review board. A total of 10 subjects between the ages of 18 and 72 with ≥20% total body surface area burn were enrolled over a 14-month period. Data were collected for five subjects (average age of 28 ± 8 years and total body surface area burn of 69 ± 15%) who met the inclusion criteria. Changes in visceral protein levels were examined along with nitrogen balance and acute-phase reactants when the subjects were on enteral nutrition, and the proteins were not examined during times of acute kidney injury. Descriptive statistics were performed, and linear regression was used to analyze the association of visceral proteins and nitrogen balance during times that acute-phase reactant levels were decreasing. The subjects received an average of 3044 ± 1613 kcal/day (39 ± 20 kcal/kg), meeting 72% of caloric goals and achieving positive nitrogen balance during 68% of the 40 weekly measurements, with 174 ± 85 g of protein intake per day (2.2 ± 1.1 g/kg). There was a weak relationship between nitrogen balance and changes in visceral protein levels during times that the acute-phase reactant levels were decreasing (P >.05). Visceral proteins were found to be poor markers of nutritional status. This study is unique because the subjects were able to achieve positive nitrogen balance despite severe burns.

UR - http://www.scopus.com/inward/record.url?scp=84937638860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937638860&partnerID=8YFLogxK

U2 - 10.1097/BCR.0000000000000101

DO - 10.1097/BCR.0000000000000101

M3 - Article

C2 - 25055006

AN - SCOPUS:84937638860

VL - 36

SP - 375

EP - 380

JO - Journal of Burn Care and Research

JF - Journal of Burn Care and Research

SN - 1559-047X

IS - 3

ER -