Abstract
In the current issue of Critical Care, Simon and coworkers investigated the effects of first-line arginine vasopressin (AVP) on organ function and systemic metabolism compared with norepinephrine in a pig model of fecal peritonitis. AVP was titrated according to the mean arterial pressure suggesting a vasopressor rather than a hormone replacement therapy. The study provides some evidence for the safety of this therapeutic approach. It needs to be determined whether AVP is most beneficial as a constant low-dose infusion to supplement norepinephrine or in higher doses than currently recommended to substitute norepinephrine. In addition, future studies are warranted to evaluate whether a first-line therapy of AVP is superior to a last-resort administration.
Original language | English (US) |
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Pages (from-to) | 178 |
Number of pages | 1 |
Journal | Critical care (London, England) |
Volume | 13 |
Issue number | 4 |
DOIs |
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State | Published - 2009 |
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine