Arginine vasopressin in septic shock: supplement or substitute for norepinephrine?

Sebastian Rehberg, Perenlei Enkhbaatar, Daniel L. Traber

Research output: Contribution to journalComment/debatepeer-review

1 Scopus citations


In the current issue of Critical Care, Simon and coworkers investigated the effects of first-line arginine vasopressin (AVP) on organ function and systemic metabolism compared with norepinephrine in a pig model of fecal peritonitis. AVP was titrated according to the mean arterial pressure suggesting a vasopressor rather than a hormone replacement therapy. The study provides some evidence for the safety of this therapeutic approach. It needs to be determined whether AVP is most beneficial as a constant low-dose infusion to supplement norepinephrine or in higher doses than currently recommended to substitute norepinephrine. In addition, future studies are warranted to evaluate whether a first-line therapy of AVP is superior to a last-resort administration.

Original languageEnglish (US)
Pages (from-to)178
Number of pages1
JournalCritical care (London, England)
Issue number4
StatePublished - 2009

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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