Arginine vasopressin in the cytoplasm and nuclear fraction of lymphocytes from healthy donors and patients with depression or schizophrenia

Rolf Ekman, Johan Gobom, Rita Persson, Patrizia Mecocci, Carol L. Nilsson

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We investigated whether cytoplasmic or nuclear extracts of human peripheral blood lymphocytes contain AVP in samples from healthy controls and patients diagnosed as depressed or schizophrenic. Both the cytoplasmic and nuclear extracts contained AVP as determined by radioimmunoassay. AVP and other peptides were detected in the purified samples by matrix-assisted laser desorption/ionization time of flight mass spectrometry. It is the first time that AVP has been characterized in human lymphocytes of patients with depression or schizophrenia. This finding demonstrates the presence of another important component within the potential regulatory loop between immune and neuro-endocrine tissues.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalPeptides
Volume22
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Lymphocytes
Arginine Vasopressin
Schizophrenia
Cytoplasm
Tissue Donors
Depression
Ionization
Radioimmunoassay
Mass spectrometry
Desorption
Mass Spectrometry
Lasers
Blood
Tissue
Peptides

Keywords

  • Arginine vasopressin
  • High-performance liquid chromatography (HPLC)
  • Lymphocytes
  • Mass spectrometry
  • Radioimmunoassay

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Arginine vasopressin in the cytoplasm and nuclear fraction of lymphocytes from healthy donors and patients with depression or schizophrenia. / Ekman, Rolf; Gobom, Johan; Persson, Rita; Mecocci, Patrizia; Nilsson, Carol L.

In: Peptides, Vol. 22, No. 1, 2001, p. 67-72.

Research output: Contribution to journalArticle

Ekman, Rolf ; Gobom, Johan ; Persson, Rita ; Mecocci, Patrizia ; Nilsson, Carol L. / Arginine vasopressin in the cytoplasm and nuclear fraction of lymphocytes from healthy donors and patients with depression or schizophrenia. In: Peptides. 2001 ; Vol. 22, No. 1. pp. 67-72.
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