Arginine vasopressin in the cytoplasm and nuclear fraction of lymphocytes from healthy donors and patients with depression or schizophrenia

Rolf Ekman, Johan Gobom, Rita Persson, Patrizia Mecocci, Carol L. Nilsson

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

We investigated whether cytoplasmic or nuclear extracts of human peripheral blood lymphocytes contain AVP in samples from healthy controls and patients diagnosed as depressed or schizophrenic. Both the cytoplasmic and nuclear extracts contained AVP as determined by radioimmunoassay. AVP and other peptides were detected in the purified samples by matrix-assisted laser desorption/ionization time of flight mass spectrometry. It is the first time that AVP has been characterized in human lymphocytes of patients with depression or schizophrenia. This finding demonstrates the presence of another important component within the potential regulatory loop between immune and neuro-endocrine tissues.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalPeptides
Volume22
Issue number1
DOIs
StatePublished - 2001

Keywords

  • Arginine vasopressin
  • High-performance liquid chromatography (HPLC)
  • Lymphocytes
  • Mass spectrometry
  • Radioimmunoassay

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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