Arrangement of the Polymerase Complexes inside a Nine-Segmented dsRNA Virus

Jason T. Kaelber; Wen Jiang; Scott C. Weaver; Albert Auguste; Wah Chiu

doi:10.1016/j.str.2020.01.011

Arrangement of the Polymerase Complexes inside a Nine-Segmented dsRNA Virus

Jason T. Kaelber, Wen Jiang, Scott C. Weaver, Albert Auguste, Wah Chiu

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The arrangement of polymerases inside an unusual nine-segmented dsRNA virus was determined by Kaelber et al. While cryo-EM is typically used to average copies of a protein into one structure, they also compared raw images with synthetic maps to test whether subsets of virions had different arrangements.

Original language	English (US)
Pages (from-to)	604-612.e3
Journal	Structure
Volume	28
Issue number	6
DOIs	https://doi.org/10.1016/j.str.2020.01.011
State	Published - Jun 2 2020
Externally published	Yes

Keywords

RNA-dependent RNA polymerase
Reoviridae
asymmetric reconstruction
cryo-EM reconstruction
single particle

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/j.str.2020.01.011

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title = "Arrangement of the Polymerase Complexes inside a Nine-Segmented dsRNA Virus",

abstract = "The arrangement of polymerases inside an unusual nine-segmented dsRNA virus was determined by Kaelber et al. While cryo-EM is typically used to average copies of a protein into one structure, they also compared raw images with synthetic maps to test whether subsets of virions had different arrangements.",

keywords = "RNA-dependent RNA polymerase, Reoviridae, asymmetric reconstruction, cryo-EM reconstruction, single particle",

author = "Kaelber, {Jason T.} and Wen Jiang and Weaver, {Scott C.} and Albert Auguste and Wah Chiu",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = jun,

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doi = "10.1016/j.str.2020.01.011",

language = "English (US)",

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AU - Kaelber, Jason T.

AU - Jiang, Wen

AU - Weaver, Scott C.

AU - Auguste, Albert

AU - Chiu, Wah

PY - 2020/6/2

Y1 - 2020/6/2

N2 - The arrangement of polymerases inside an unusual nine-segmented dsRNA virus was determined by Kaelber et al. While cryo-EM is typically used to average copies of a protein into one structure, they also compared raw images with synthetic maps to test whether subsets of virions had different arrangements.

AB - The arrangement of polymerases inside an unusual nine-segmented dsRNA virus was determined by Kaelber et al. While cryo-EM is typically used to average copies of a protein into one structure, they also compared raw images with synthetic maps to test whether subsets of virions had different arrangements.

KW - RNA-dependent RNA polymerase

KW - Reoviridae

KW - asymmetric reconstruction

KW - cryo-EM reconstruction

KW - single particle

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Arrangement of the Polymerase Complexes inside a Nine-Segmented dsRNA Virus

Abstract

Keywords

ASJC Scopus subject areas

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