Arthritis and cognitive impairment in older adults

Nancy A. Baker, Kamil E. Barbour, Charles G. Helmick, Matthew Zack, Soham Al Snih al snih

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    Adults aged 65 or older with arthritis may be at increased risk for cognitive impairment [cognitive impairment but not dementia (CIND) or dementia]. Studies have found associations between arthritis and cognition impairments; however, none have examined whether persons with arthritis develop cognitive impairments at higher rates than those without arthritis. Using data from the Health and Retirement Study, we estimated the prevalence of cognitive impairments in older adults with and without arthritis, and examined associations between arthritis status and cognitive impairments. We calculated incidence density ratios (IDRs) using generalized estimating equations to estimate associations between arthritis and cognitive impairments adjusting for age, sex, race/ethnicity, marital status, education, income, depression, obesity, smoking, the number of chronic conditions, physical activity, and birth cohort. The prevalence of CIND and dementia did not significantly differ between those with and without arthritis (CIND: 20.8%, 95% CI 19.7–21.9 vs. 18.3%, 95% CI 16.8–19.8; dementia: 5.2% 95% CI 4.6–5.8 vs. 5.1% 95% CI 4.3–5.9). After covariate control, older adults with arthritis did not differ significantly from those without arthritis for either cognitive outcome (CIND IDR: 1.6, 95% CI = 0.9–2.9; dementia IDR: 1.1, 95% CI = 0.4–3.3) and developed cognitive impairments at a similar rate to those without arthritis. Older adults with arthritis were not significantly more at risk to develop cognitive impairments and developed cognitive impairments at a similar rate as older adults without arthritis over 6 years.

    Original languageEnglish (US)
    Pages (from-to)1-7
    Number of pages7
    JournalRheumatology International
    DOIs
    StateAccepted/In press - Mar 23 2017

    Fingerprint

    Arthritis
    Dementia
    Cognitive Dysfunction
    Incidence
    Retirement
    Marital Status
    Cognition
    Obesity
    Cross-Sectional Studies
    Smoking
    Parturition
    Exercise
    Depression
    Education

    Keywords

    • Aging
    • Cognitive impairment but not dementia
    • Dementia
    • Epidemiology

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Rheumatology
    • Immunology

    Cite this

    Arthritis and cognitive impairment in older adults. / Baker, Nancy A.; Barbour, Kamil E.; Helmick, Charles G.; Zack, Matthew; Al Snih al snih, Soham.

    In: Rheumatology International, 23.03.2017, p. 1-7.

    Research output: Contribution to journalArticle

    Baker, Nancy A. ; Barbour, Kamil E. ; Helmick, Charles G. ; Zack, Matthew ; Al Snih al snih, Soham. / Arthritis and cognitive impairment in older adults. In: Rheumatology International. 2017 ; pp. 1-7.
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    abstract = "Adults aged 65 or older with arthritis may be at increased risk for cognitive impairment [cognitive impairment but not dementia (CIND) or dementia]. Studies have found associations between arthritis and cognition impairments; however, none have examined whether persons with arthritis develop cognitive impairments at higher rates than those without arthritis. Using data from the Health and Retirement Study, we estimated the prevalence of cognitive impairments in older adults with and without arthritis, and examined associations between arthritis status and cognitive impairments. We calculated incidence density ratios (IDRs) using generalized estimating equations to estimate associations between arthritis and cognitive impairments adjusting for age, sex, race/ethnicity, marital status, education, income, depression, obesity, smoking, the number of chronic conditions, physical activity, and birth cohort. The prevalence of CIND and dementia did not significantly differ between those with and without arthritis (CIND: 20.8{\%}, 95{\%} CI 19.7–21.9 vs. 18.3{\%}, 95{\%} CI 16.8–19.8; dementia: 5.2{\%} 95{\%} CI 4.6–5.8 vs. 5.1{\%} 95{\%} CI 4.3–5.9). After covariate control, older adults with arthritis did not differ significantly from those without arthritis for either cognitive outcome (CIND IDR: 1.6, 95{\%} CI = 0.9–2.9; dementia IDR: 1.1, 95{\%} CI = 0.4–3.3) and developed cognitive impairments at a similar rate to those without arthritis. Older adults with arthritis were not significantly more at risk to develop cognitive impairments and developed cognitive impairments at a similar rate as older adults without arthritis over 6 years.",
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