Arthritis syndromes associated with human T cell lymphotropic virus type I infection

R. M. McCallum, D. D. Patel, J. O. Moore, B. F. Haynes

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Arthritis syndromes occur associated with HTLV-I infection both in the presence and in the absence of clinical ATL, and polyarthritis may be the presenting manifestation of HTLV-I-associated ATL. In both clinical settings, HTLV-I-infected T cells home to affected joints, and tax-transgenic mouse studies have suggested a pathogenic role for the HTLV-I tax gene in inducing synovial cell proliferation in HAA. Understanding the pathogenesis of rheumatoid arthritis-like arthritis syndromes that occur in the setting of HTLV-I infection should also provide insights into understanding of cellular and molecular mechanisms of synovial cell proliferation in HTLV-I-negative rheumatoid arthritis.

Original languageEnglish (US)
Pages (from-to)261-276
Number of pages16
JournalMedical Clinics of North America
Volume81
Issue number1
DOIs
StatePublished - 1997
Externally publishedYes

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Human T-lymphotropic virus 1
Virus Diseases
HTLV-I Infections
Arthritis
T-Lymphocytes
Rheumatoid Arthritis
pX Genes
Cell Proliferation
Transgenic Mice
Joints

ASJC Scopus subject areas

  • Medicine(all)

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Arthritis syndromes associated with human T cell lymphotropic virus type I infection. / McCallum, R. M.; Patel, D. D.; Moore, J. O.; Haynes, B. F.

In: Medical Clinics of North America, Vol. 81, No. 1, 1997, p. 261-276.

Research output: Contribution to journalArticle

McCallum, R. M. ; Patel, D. D. ; Moore, J. O. ; Haynes, B. F. / Arthritis syndromes associated with human T cell lymphotropic virus type I infection. In: Medical Clinics of North America. 1997 ; Vol. 81, No. 1. pp. 261-276.
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