Artificial lung prototype development

S. D. Lick, S. K. Alpard, P. Montoya, D. J. Deyo, J. B. Jayroe, J. B. Zwischenberger

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    We are developing a low-resistance artificial lung for ambulatory medium-term use (weeks to months) as a potential bridge to transplant or recovery using a sheep survival model. Ventricular assist device (VAD) arterial cannulae are anastomosed to the proximal and distal main pulmonary artery, and an inflatable occluder is placed between, which, when inflated, diverts full main pulmonary artery flow through the artificial lung. The cannulae attach via 5/8' connectors to a rigidly housed, low resistance, microporous hollow fiber membrane gas exchanger (artificial lung, MC3, Inc. Ann Arbor, MI: 2.25m2, priming volume 350cc). 8/8 animals have survived the implant. Two were electively sacrificed after 7 days. The others died either of late exsanguination (3 sheep), insanguination into the chest from a late anastomotic dehiscence (surgical technique error, 1 sheep), or right heart failure (two sheep). Causes of exsanguination were broken blood ports (2 deaths) or cannula disconnection (1 death). Based on this experience, we have made 3 separate modifications: 1) removal of blood sampling ports; 2) change from slip-on cannula connectors to a more secure collet-nut configuration; and 3) lower resistance artificial lung (mean gradient at total PA flow from 8 mmHg to 6 mmHg) by improving blood flow patterns. A rigidly housed, low-resistance gas exchanger can function as a chronic artificial lung when interposed to accommodate total pulmonary artery blood flow.

    Original languageEnglish (US)
    Pages (from-to)230
    Number of pages1
    JournalASAIO Journal
    Volume46
    Issue number2
    StatePublished - Mar 2000

    Fingerprint

    Blood
    Sheep
    Lung
    Exsanguination
    Pulmonary Artery
    Gases
    Transplants
    Medical Errors
    Heart-Assist Devices
    Nuts
    Flow patterns
    Animals
    Sampling
    Membranes
    Recovery
    Thorax
    Heart Failure
    Fibers
    Cannula

    ASJC Scopus subject areas

    • Biophysics
    • Bioengineering

    Cite this

    Lick, S. D., Alpard, S. K., Montoya, P., Deyo, D. J., Jayroe, J. B., & Zwischenberger, J. B. (2000). Artificial lung prototype development. ASAIO Journal, 46(2), 230.

    Artificial lung prototype development. / Lick, S. D.; Alpard, S. K.; Montoya, P.; Deyo, D. J.; Jayroe, J. B.; Zwischenberger, J. B.

    In: ASAIO Journal, Vol. 46, No. 2, 03.2000, p. 230.

    Research output: Contribution to journalArticle

    Lick, SD, Alpard, SK, Montoya, P, Deyo, DJ, Jayroe, JB & Zwischenberger, JB 2000, 'Artificial lung prototype development', ASAIO Journal, vol. 46, no. 2, pp. 230.
    Lick SD, Alpard SK, Montoya P, Deyo DJ, Jayroe JB, Zwischenberger JB. Artificial lung prototype development. ASAIO Journal. 2000 Mar;46(2):230.
    Lick, S. D. ; Alpard, S. K. ; Montoya, P. ; Deyo, D. J. ; Jayroe, J. B. ; Zwischenberger, J. B. / Artificial lung prototype development. In: ASAIO Journal. 2000 ; Vol. 46, No. 2. pp. 230.
    @article{df65a81480244e67990fd7e97e3ff304,
    title = "Artificial lung prototype development",
    abstract = "We are developing a low-resistance artificial lung for ambulatory medium-term use (weeks to months) as a potential bridge to transplant or recovery using a sheep survival model. Ventricular assist device (VAD) arterial cannulae are anastomosed to the proximal and distal main pulmonary artery, and an inflatable occluder is placed between, which, when inflated, diverts full main pulmonary artery flow through the artificial lung. The cannulae attach via 5/8' connectors to a rigidly housed, low resistance, microporous hollow fiber membrane gas exchanger (artificial lung, MC3, Inc. Ann Arbor, MI: 2.25m2, priming volume 350cc). 8/8 animals have survived the implant. Two were electively sacrificed after 7 days. The others died either of late exsanguination (3 sheep), insanguination into the chest from a late anastomotic dehiscence (surgical technique error, 1 sheep), or right heart failure (two sheep). Causes of exsanguination were broken blood ports (2 deaths) or cannula disconnection (1 death). Based on this experience, we have made 3 separate modifications: 1) removal of blood sampling ports; 2) change from slip-on cannula connectors to a more secure collet-nut configuration; and 3) lower resistance artificial lung (mean gradient at total PA flow from 8 mmHg to 6 mmHg) by improving blood flow patterns. A rigidly housed, low-resistance gas exchanger can function as a chronic artificial lung when interposed to accommodate total pulmonary artery blood flow.",
    author = "Lick, {S. D.} and Alpard, {S. K.} and P. Montoya and Deyo, {D. J.} and Jayroe, {J. B.} and Zwischenberger, {J. B.}",
    year = "2000",
    month = "3",
    language = "English (US)",
    volume = "46",
    pages = "230",
    journal = "ASAIO Journal",
    issn = "1058-2916",
    publisher = "Lippincott Williams and Wilkins",
    number = "2",

    }

    TY - JOUR

    T1 - Artificial lung prototype development

    AU - Lick, S. D.

    AU - Alpard, S. K.

    AU - Montoya, P.

    AU - Deyo, D. J.

    AU - Jayroe, J. B.

    AU - Zwischenberger, J. B.

    PY - 2000/3

    Y1 - 2000/3

    N2 - We are developing a low-resistance artificial lung for ambulatory medium-term use (weeks to months) as a potential bridge to transplant or recovery using a sheep survival model. Ventricular assist device (VAD) arterial cannulae are anastomosed to the proximal and distal main pulmonary artery, and an inflatable occluder is placed between, which, when inflated, diverts full main pulmonary artery flow through the artificial lung. The cannulae attach via 5/8' connectors to a rigidly housed, low resistance, microporous hollow fiber membrane gas exchanger (artificial lung, MC3, Inc. Ann Arbor, MI: 2.25m2, priming volume 350cc). 8/8 animals have survived the implant. Two were electively sacrificed after 7 days. The others died either of late exsanguination (3 sheep), insanguination into the chest from a late anastomotic dehiscence (surgical technique error, 1 sheep), or right heart failure (two sheep). Causes of exsanguination were broken blood ports (2 deaths) or cannula disconnection (1 death). Based on this experience, we have made 3 separate modifications: 1) removal of blood sampling ports; 2) change from slip-on cannula connectors to a more secure collet-nut configuration; and 3) lower resistance artificial lung (mean gradient at total PA flow from 8 mmHg to 6 mmHg) by improving blood flow patterns. A rigidly housed, low-resistance gas exchanger can function as a chronic artificial lung when interposed to accommodate total pulmonary artery blood flow.

    AB - We are developing a low-resistance artificial lung for ambulatory medium-term use (weeks to months) as a potential bridge to transplant or recovery using a sheep survival model. Ventricular assist device (VAD) arterial cannulae are anastomosed to the proximal and distal main pulmonary artery, and an inflatable occluder is placed between, which, when inflated, diverts full main pulmonary artery flow through the artificial lung. The cannulae attach via 5/8' connectors to a rigidly housed, low resistance, microporous hollow fiber membrane gas exchanger (artificial lung, MC3, Inc. Ann Arbor, MI: 2.25m2, priming volume 350cc). 8/8 animals have survived the implant. Two were electively sacrificed after 7 days. The others died either of late exsanguination (3 sheep), insanguination into the chest from a late anastomotic dehiscence (surgical technique error, 1 sheep), or right heart failure (two sheep). Causes of exsanguination were broken blood ports (2 deaths) or cannula disconnection (1 death). Based on this experience, we have made 3 separate modifications: 1) removal of blood sampling ports; 2) change from slip-on cannula connectors to a more secure collet-nut configuration; and 3) lower resistance artificial lung (mean gradient at total PA flow from 8 mmHg to 6 mmHg) by improving blood flow patterns. A rigidly housed, low-resistance gas exchanger can function as a chronic artificial lung when interposed to accommodate total pulmonary artery blood flow.

    UR - http://www.scopus.com/inward/record.url?scp=0034158866&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0034158866&partnerID=8YFLogxK

    M3 - Article

    AN - SCOPUS:0034158866

    VL - 46

    SP - 230

    JO - ASAIO Journal

    JF - ASAIO Journal

    SN - 1058-2916

    IS - 2

    ER -