Abstract
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor responsive to both natural and man-made environmental compounds. AhR-mediated changes in gene expression frequently affect cell growth, and recent evidence reveals a direct role for the AhR in cell cycle control. This review examines the functional interaction between the AhR and the retinoblastoma tumor suppressor protein (pRb), and its impact on the G1 phase of the cell cycle. The discussion emphasizes gaps in our mechanistic understanding, and reveals the AhR signaling pathway as a novel drug target to control cell proliferation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 261-267 |
| Number of pages | 7 |
| Journal | Progress in cell cycle research |
| Volume | 5 |
| State | Published - 2003 |
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Aryl hydrocarbon receptor-mediated cell cycle control. / Elferink, Cornelis.
In: Progress in cell cycle research, Vol. 5, 2003, p. 261-267.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Aryl hydrocarbon receptor-mediated cell cycle control.
AU - Elferink, Cornelis
PY - 2003
Y1 - 2003
N2 - The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor responsive to both natural and man-made environmental compounds. AhR-mediated changes in gene expression frequently affect cell growth, and recent evidence reveals a direct role for the AhR in cell cycle control. This review examines the functional interaction between the AhR and the retinoblastoma tumor suppressor protein (pRb), and its impact on the G1 phase of the cell cycle. The discussion emphasizes gaps in our mechanistic understanding, and reveals the AhR signaling pathway as a novel drug target to control cell proliferation.
AB - The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor responsive to both natural and man-made environmental compounds. AhR-mediated changes in gene expression frequently affect cell growth, and recent evidence reveals a direct role for the AhR in cell cycle control. This review examines the functional interaction between the AhR and the retinoblastoma tumor suppressor protein (pRb), and its impact on the G1 phase of the cell cycle. The discussion emphasizes gaps in our mechanistic understanding, and reveals the AhR signaling pathway as a novel drug target to control cell proliferation.
UR - http://www.scopus.com/inward/record.url?scp=0642286536&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0642286536&partnerID=8YFLogxK
M3 - Article
C2 - 14593720
AN - SCOPUS:0642286536
VL - 5
SP - 261
EP - 267
JO - Progress in cell cycle research
JF - Progress in cell cycle research
SN - 1087-2957
ER -