Aryl hydrocarbon receptor-mediated cell cycle control.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor responsive to both natural and man-made environmental compounds. AhR-mediated changes in gene expression frequently affect cell growth, and recent evidence reveals a direct role for the AhR in cell cycle control. This review examines the functional interaction between the AhR and the retinoblastoma tumor suppressor protein (pRb), and its impact on the G1 phase of the cell cycle. The discussion emphasizes gaps in our mechanistic understanding, and reveals the AhR signaling pathway as a novel drug target to control cell proliferation.

Original languageEnglish (US)
Pages (from-to)261-267
Number of pages7
JournalProgress in cell cycle research
Volume5
StatePublished - 2003

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Aryl Hydrocarbon Receptors
Cell Cycle Checkpoints
Tumor Suppressor Proteins
Retinoblastoma Protein
G1 Phase
Cell Cycle
Transcription Factors
Cell Proliferation
Ligands
Gene Expression
Growth
Pharmaceutical Preparations

Cite this

Aryl hydrocarbon receptor-mediated cell cycle control. / Elferink, Cornelis.

In: Progress in cell cycle research, Vol. 5, 2003, p. 261-267.

Research output: Contribution to journalArticle

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