Ascending pressor and depressor pathways in the cat spinal cord

Jin Chung, R. D. Wurster

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Citations (Scopus)

Abstract

Blood pressure responses to stimulation of the cervical dorsolateral sulcus (DLS) of the spinal cord and lumbar dorsal roots were studied in anesthetized, vagotomized, and paralyzed cats. Stimulation of the lumbar dorsal roots elicited pressor responses with high frequency stimulation (50 Hz, 10 V, 1 ms) and depressor responses with low frequency stimulation (1 Hz, 10 V, 1 ms). Pressor responses were converted to depressor responses after bilateral lesions were made in the DLS area rostral to the site of stimulation. These results suggest that the ascending spinal pressor pathways are localized in the DLS region. Furthermore, these depressor responses were abolished by placing additional bilateral lesions in the dorsolateral funiculus (DLF) rostral to the site of stimulation. These data indicate the presence of ascending depressor pathways in the DLF which are anatomically separate from pressor pathways. Both pathways were found to be bilateral systems, and decussation of fibers appears to be complete within three segments rostral to their entry into the spinal cord. Ascending depressor pathways have a low optimal frequency of activation, as opposed to the ascending pressor pathways which have a relatively high optimal frequency of activation. Neurophysiological evidence obtained by recording unit activity from the cervical sympathetic trunk confirmed the localization of the ascending pressor and depressor pathways.

Original languageEnglish (US)
Title of host publicationAmerican Journal of Physiology
Pages786-792
Number of pages7
Volume231
Edition3
StatePublished - 1976
Externally publishedYes

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Spinal Nerve Roots
Spinal Cord
Cats
Blood Pressure

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chung, J., & Wurster, R. D. (1976). Ascending pressor and depressor pathways in the cat spinal cord. In American Journal of Physiology (3 ed., Vol. 231, pp. 786-792)

Ascending pressor and depressor pathways in the cat spinal cord. / Chung, Jin; Wurster, R. D.

American Journal of Physiology. Vol. 231 3. ed. 1976. p. 786-792.

Research output: Chapter in Book/Report/Conference proceedingChapter

Chung, J & Wurster, RD 1976, Ascending pressor and depressor pathways in the cat spinal cord. in American Journal of Physiology. 3 edn, vol. 231, pp. 786-792.
Chung J, Wurster RD. Ascending pressor and depressor pathways in the cat spinal cord. In American Journal of Physiology. 3 ed. Vol. 231. 1976. p. 786-792
Chung, Jin ; Wurster, R. D. / Ascending pressor and depressor pathways in the cat spinal cord. American Journal of Physiology. Vol. 231 3. ed. 1976. pp. 786-792
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