Ascorbate-induced release of LHRH: Noradrenergic and opioid modulation

Brian T. Miller, Theodore J. Cicero

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    Ascorbic acid caused a calcium-dependent release of luteinizing hormone-releasing hormone (LHRH) from the rat mediobasal hypothalamus in vitro. The ascorbate-induced release of LHRH was effectively blocked by the adrenergic α-receptor blocker phentolamine, but not by the β-receptor blocker propranolol. The effect of ascorbate was also suppressed by the mu receptor selective opiate agonist sufentanil. These results suggest that the effects of ascorbic acid on the in vitro release of LHRH are mediated by endogenous norepinephrine. Moreover, our results are consistent with the hypothesis that the release of LHRH in the rat is regulated by the hypothalamic noradrenergic system, which is in turn modulated in some, as yet undetermined, fashion by opioid peptides.

    Original languageEnglish (US)
    Pages (from-to)95-99
    Number of pages5
    JournalBrain Research Bulletin
    Volume19
    Issue number1
    DOIs
    StatePublished - 1987

    Fingerprint

    Gonadotropin-Releasing Hormone
    Opioid Analgesics
    Ascorbic Acid
    Opiate Alkaloids
    Sufentanil
    Adrenergic Antagonists
    Opioid Peptides
    mu Opioid Receptor
    Phentolamine
    Propranolol
    Adrenergic Receptors
    Hypothalamus
    Norepinephrine
    Calcium
    In Vitro Techniques

    Keywords

    • Ascorbic acid
    • Endogenous opioid peptides
    • Hypothalamus
    • LHRH
    • Noradrenergic receptors
    • Noradrenergic system
    • Opioid receptors

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Ascorbate-induced release of LHRH : Noradrenergic and opioid modulation. / Miller, Brian T.; Cicero, Theodore J.

    In: Brain Research Bulletin, Vol. 19, No. 1, 1987, p. 95-99.

    Research output: Contribution to journalArticle

    Miller, Brian T. ; Cicero, Theodore J. / Ascorbate-induced release of LHRH : Noradrenergic and opioid modulation. In: Brain Research Bulletin. 1987 ; Vol. 19, No. 1. pp. 95-99.
    @article{95fb133aa1d14828835d5a8a06ad7668,
    title = "Ascorbate-induced release of LHRH: Noradrenergic and opioid modulation",
    abstract = "Ascorbic acid caused a calcium-dependent release of luteinizing hormone-releasing hormone (LHRH) from the rat mediobasal hypothalamus in vitro. The ascorbate-induced release of LHRH was effectively blocked by the adrenergic α-receptor blocker phentolamine, but not by the β-receptor blocker propranolol. The effect of ascorbate was also suppressed by the mu receptor selective opiate agonist sufentanil. These results suggest that the effects of ascorbic acid on the in vitro release of LHRH are mediated by endogenous norepinephrine. Moreover, our results are consistent with the hypothesis that the release of LHRH in the rat is regulated by the hypothalamic noradrenergic system, which is in turn modulated in some, as yet undetermined, fashion by opioid peptides.",
    keywords = "Ascorbic acid, Endogenous opioid peptides, Hypothalamus, LHRH, Noradrenergic receptors, Noradrenergic system, Opioid receptors",
    author = "Miller, {Brian T.} and Cicero, {Theodore J.}",
    year = "1987",
    doi = "10.1016/0361-9230(87)90171-7",
    language = "English (US)",
    volume = "19",
    pages = "95--99",
    journal = "Brain Research Bulletin",
    issn = "0361-9230",
    publisher = "Elsevier Inc.",
    number = "1",

    }

    TY - JOUR

    T1 - Ascorbate-induced release of LHRH

    T2 - Noradrenergic and opioid modulation

    AU - Miller, Brian T.

    AU - Cicero, Theodore J.

    PY - 1987

    Y1 - 1987

    N2 - Ascorbic acid caused a calcium-dependent release of luteinizing hormone-releasing hormone (LHRH) from the rat mediobasal hypothalamus in vitro. The ascorbate-induced release of LHRH was effectively blocked by the adrenergic α-receptor blocker phentolamine, but not by the β-receptor blocker propranolol. The effect of ascorbate was also suppressed by the mu receptor selective opiate agonist sufentanil. These results suggest that the effects of ascorbic acid on the in vitro release of LHRH are mediated by endogenous norepinephrine. Moreover, our results are consistent with the hypothesis that the release of LHRH in the rat is regulated by the hypothalamic noradrenergic system, which is in turn modulated in some, as yet undetermined, fashion by opioid peptides.

    AB - Ascorbic acid caused a calcium-dependent release of luteinizing hormone-releasing hormone (LHRH) from the rat mediobasal hypothalamus in vitro. The ascorbate-induced release of LHRH was effectively blocked by the adrenergic α-receptor blocker phentolamine, but not by the β-receptor blocker propranolol. The effect of ascorbate was also suppressed by the mu receptor selective opiate agonist sufentanil. These results suggest that the effects of ascorbic acid on the in vitro release of LHRH are mediated by endogenous norepinephrine. Moreover, our results are consistent with the hypothesis that the release of LHRH in the rat is regulated by the hypothalamic noradrenergic system, which is in turn modulated in some, as yet undetermined, fashion by opioid peptides.

    KW - Ascorbic acid

    KW - Endogenous opioid peptides

    KW - Hypothalamus

    KW - LHRH

    KW - Noradrenergic receptors

    KW - Noradrenergic system

    KW - Opioid receptors

    UR - http://www.scopus.com/inward/record.url?scp=0023585032&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0023585032&partnerID=8YFLogxK

    U2 - 10.1016/0361-9230(87)90171-7

    DO - 10.1016/0361-9230(87)90171-7

    M3 - Article

    C2 - 2820553

    AN - SCOPUS:0023585032

    VL - 19

    SP - 95

    EP - 99

    JO - Brain Research Bulletin

    JF - Brain Research Bulletin

    SN - 0361-9230

    IS - 1

    ER -