Ascorbate-induced release of LHRH: Noradrenergic and opioid modulation

Brian T. Miller, Theodore J. Cicero

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Ascorbic acid caused a calcium-dependent release of luteinizing hormone-releasing hormone (LHRH) from the rat mediobasal hypothalamus in vitro. The ascorbate-induced release of LHRH was effectively blocked by the adrenergic α-receptor blocker phentolamine, but not by the β-receptor blocker propranolol. The effect of ascorbate was also suppressed by the mu receptor selective opiate agonist sufentanil. These results suggest that the effects of ascorbic acid on the in vitro release of LHRH are mediated by endogenous norepinephrine. Moreover, our results are consistent with the hypothesis that the release of LHRH in the rat is regulated by the hypothalamic noradrenergic system, which is in turn modulated in some, as yet undetermined, fashion by opioid peptides.

Original languageEnglish (US)
Pages (from-to)95-99
Number of pages5
JournalBrain Research Bulletin
Issue number1
StatePublished - Jul 1987
Externally publishedYes


  • Ascorbic acid
  • Endogenous opioid peptides
  • Hypothalamus
  • LHRH
  • Noradrenergic receptors
  • Noradrenergic system
  • Opioid receptors

ASJC Scopus subject areas

  • General Neuroscience


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