Ascorbic acid deficiency in porphyria cutanea tarda

Peter R. Sinclair, Nadia Gorman, Steven I. Shedlofsky, Charles P. Honsinger, Jacqueline F. Sinclair, Margaret R. Karagas, Karl Anderson

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Porphyria cutanea tarda (PCT), the most common form of porphyria, is manifested as skin photosensitivity caused by excess hepatic production of uroporphyrin and heptacarboxylporphyrin. In experimental animal models, ascorbic acid modulates chemically induced uroporphyrin accumulation. The purpose of this study was to determine whether ascorbic acid is decreased in the plasma of patients with PCT. Plasma was obtained after an overnight fast from 21 PCT patients, 16 of whom were infected with hepatitis C virus (HCV), and from a separate group of 9 patients with HCV infection but not PCT. Thirteen PCT patients were studied when they had active disease and 8 after treatment-induced remission. Plasma ascorbic acid was low (<23 μmol/L) in 11 (85%) of the 13 untreated PCT patients and deficient (<11 μmol/L) in 8 (62%). Two patients with normal ascorbic acid levels (45 and 62 μmmol/L) had consumed multivitamins. In 2 patients with deficient ascorbic acid, plasma levels returned to normal after phlebotomy treatment. Of the 8 patients studied during remission, 4 had normal ascorbic acid values and 4 were deficient (5 to 8 μmol/L). Plasma ascorbic acid values were normal for all patients who had HCV but no PCT. These data suggest that plasma ascorbic acid concentrations are commonly low in PCT, but this decrease is unrelated to HCV infection. Ascorbic acid deficiency may be one of the factors that contributes to the pathogenesis of PCT.

Original languageEnglish (US)
Pages (from-to)197-201
Number of pages5
JournalJournal of Laboratory and Clinical Medicine
Volume130
Issue number2
StatePublished - Aug 1997
Externally publishedYes

Fingerprint

Ascorbic Acid Deficiency
Porphyria Cutanea Tarda
Ascorbic Acid
Plasmas
Viruses
Hepacivirus
Uroporphyrins
Virus Diseases
Porphyrias
Photosensitivity
Phlebotomy
Skin
Reference Values
Animals
Animal Models

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Sinclair, P. R., Gorman, N., Shedlofsky, S. I., Honsinger, C. P., Sinclair, J. F., Karagas, M. R., & Anderson, K. (1997). Ascorbic acid deficiency in porphyria cutanea tarda. Journal of Laboratory and Clinical Medicine, 130(2), 197-201.

Ascorbic acid deficiency in porphyria cutanea tarda. / Sinclair, Peter R.; Gorman, Nadia; Shedlofsky, Steven I.; Honsinger, Charles P.; Sinclair, Jacqueline F.; Karagas, Margaret R.; Anderson, Karl.

In: Journal of Laboratory and Clinical Medicine, Vol. 130, No. 2, 08.1997, p. 197-201.

Research output: Contribution to journalArticle

Sinclair, PR, Gorman, N, Shedlofsky, SI, Honsinger, CP, Sinclair, JF, Karagas, MR & Anderson, K 1997, 'Ascorbic acid deficiency in porphyria cutanea tarda', Journal of Laboratory and Clinical Medicine, vol. 130, no. 2, pp. 197-201.
Sinclair PR, Gorman N, Shedlofsky SI, Honsinger CP, Sinclair JF, Karagas MR et al. Ascorbic acid deficiency in porphyria cutanea tarda. Journal of Laboratory and Clinical Medicine. 1997 Aug;130(2):197-201.
Sinclair, Peter R. ; Gorman, Nadia ; Shedlofsky, Steven I. ; Honsinger, Charles P. ; Sinclair, Jacqueline F. ; Karagas, Margaret R. ; Anderson, Karl. / Ascorbic acid deficiency in porphyria cutanea tarda. In: Journal of Laboratory and Clinical Medicine. 1997 ; Vol. 130, No. 2. pp. 197-201.
@article{75765983378d46c085e4a56153c15286,
title = "Ascorbic acid deficiency in porphyria cutanea tarda",
abstract = "Porphyria cutanea tarda (PCT), the most common form of porphyria, is manifested as skin photosensitivity caused by excess hepatic production of uroporphyrin and heptacarboxylporphyrin. In experimental animal models, ascorbic acid modulates chemically induced uroporphyrin accumulation. The purpose of this study was to determine whether ascorbic acid is decreased in the plasma of patients with PCT. Plasma was obtained after an overnight fast from 21 PCT patients, 16 of whom were infected with hepatitis C virus (HCV), and from a separate group of 9 patients with HCV infection but not PCT. Thirteen PCT patients were studied when they had active disease and 8 after treatment-induced remission. Plasma ascorbic acid was low (<23 μmol/L) in 11 (85{\%}) of the 13 untreated PCT patients and deficient (<11 μmol/L) in 8 (62{\%}). Two patients with normal ascorbic acid levels (45 and 62 μmmol/L) had consumed multivitamins. In 2 patients with deficient ascorbic acid, plasma levels returned to normal after phlebotomy treatment. Of the 8 patients studied during remission, 4 had normal ascorbic acid values and 4 were deficient (5 to 8 μmol/L). Plasma ascorbic acid values were normal for all patients who had HCV but no PCT. These data suggest that plasma ascorbic acid concentrations are commonly low in PCT, but this decrease is unrelated to HCV infection. Ascorbic acid deficiency may be one of the factors that contributes to the pathogenesis of PCT.",
author = "Sinclair, {Peter R.} and Nadia Gorman and Shedlofsky, {Steven I.} and Honsinger, {Charles P.} and Sinclair, {Jacqueline F.} and Karagas, {Margaret R.} and Karl Anderson",
year = "1997",
month = "8",
language = "English (US)",
volume = "130",
pages = "197--201",
journal = "Translational Research",
issn = "1931-5244",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - Ascorbic acid deficiency in porphyria cutanea tarda

AU - Sinclair, Peter R.

AU - Gorman, Nadia

AU - Shedlofsky, Steven I.

AU - Honsinger, Charles P.

AU - Sinclair, Jacqueline F.

AU - Karagas, Margaret R.

AU - Anderson, Karl

PY - 1997/8

Y1 - 1997/8

N2 - Porphyria cutanea tarda (PCT), the most common form of porphyria, is manifested as skin photosensitivity caused by excess hepatic production of uroporphyrin and heptacarboxylporphyrin. In experimental animal models, ascorbic acid modulates chemically induced uroporphyrin accumulation. The purpose of this study was to determine whether ascorbic acid is decreased in the plasma of patients with PCT. Plasma was obtained after an overnight fast from 21 PCT patients, 16 of whom were infected with hepatitis C virus (HCV), and from a separate group of 9 patients with HCV infection but not PCT. Thirteen PCT patients were studied when they had active disease and 8 after treatment-induced remission. Plasma ascorbic acid was low (<23 μmol/L) in 11 (85%) of the 13 untreated PCT patients and deficient (<11 μmol/L) in 8 (62%). Two patients with normal ascorbic acid levels (45 and 62 μmmol/L) had consumed multivitamins. In 2 patients with deficient ascorbic acid, plasma levels returned to normal after phlebotomy treatment. Of the 8 patients studied during remission, 4 had normal ascorbic acid values and 4 were deficient (5 to 8 μmol/L). Plasma ascorbic acid values were normal for all patients who had HCV but no PCT. These data suggest that plasma ascorbic acid concentrations are commonly low in PCT, but this decrease is unrelated to HCV infection. Ascorbic acid deficiency may be one of the factors that contributes to the pathogenesis of PCT.

AB - Porphyria cutanea tarda (PCT), the most common form of porphyria, is manifested as skin photosensitivity caused by excess hepatic production of uroporphyrin and heptacarboxylporphyrin. In experimental animal models, ascorbic acid modulates chemically induced uroporphyrin accumulation. The purpose of this study was to determine whether ascorbic acid is decreased in the plasma of patients with PCT. Plasma was obtained after an overnight fast from 21 PCT patients, 16 of whom were infected with hepatitis C virus (HCV), and from a separate group of 9 patients with HCV infection but not PCT. Thirteen PCT patients were studied when they had active disease and 8 after treatment-induced remission. Plasma ascorbic acid was low (<23 μmol/L) in 11 (85%) of the 13 untreated PCT patients and deficient (<11 μmol/L) in 8 (62%). Two patients with normal ascorbic acid levels (45 and 62 μmmol/L) had consumed multivitamins. In 2 patients with deficient ascorbic acid, plasma levels returned to normal after phlebotomy treatment. Of the 8 patients studied during remission, 4 had normal ascorbic acid values and 4 were deficient (5 to 8 μmol/L). Plasma ascorbic acid values were normal for all patients who had HCV but no PCT. These data suggest that plasma ascorbic acid concentrations are commonly low in PCT, but this decrease is unrelated to HCV infection. Ascorbic acid deficiency may be one of the factors that contributes to the pathogenesis of PCT.

UR - http://www.scopus.com/inward/record.url?scp=0031214425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031214425&partnerID=8YFLogxK

M3 - Article

VL - 130

SP - 197

EP - 201

JO - Translational Research

JF - Translational Research

SN - 1931-5244

IS - 2

ER -