Ascorbic acid enhances the cytotoxic effect of 6-hydroxydopamine for human neuroblastoma cell lines

C. Patrick Reynolds, J. Regino Perez-Polo

    Research output: Contribution to journalArticle

    15 Citations (Scopus)

    Abstract

    Determination of LD50 values showed 3 human neuroblastoma cell lines to be 2-8-fold more sensitive to 6-hydroxydopamine (6-OHDA) than a mouse sarcoma cell line. Treatment of the cells with 6-OHDA and ascorbic acid decreased the cytotoxicity of 6-OHDA for the sarcoma cells and increased cytotoxicity for the 3 neuroblastoma cell lines.

    Original languageEnglish (US)
    Pages (from-to)151-155
    Number of pages5
    JournalNeuroscience Letters
    Volume26
    Issue number2
    DOIs
    StatePublished - Oct 23 1981

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    Oxidopamine
    Neuroblastoma
    Ascorbic Acid
    Cell Line
    Sarcoma
    Lethal Dose 50

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Ascorbic acid enhances the cytotoxic effect of 6-hydroxydopamine for human neuroblastoma cell lines. / Reynolds, C. Patrick; Perez-Polo, J. Regino.

    In: Neuroscience Letters, Vol. 26, No. 2, 23.10.1981, p. 151-155.

    Research output: Contribution to journalArticle

    Reynolds, C. Patrick ; Perez-Polo, J. Regino. / Ascorbic acid enhances the cytotoxic effect of 6-hydroxydopamine for human neuroblastoma cell lines. In: Neuroscience Letters. 1981 ; Vol. 26, No. 2. pp. 151-155.
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