Ascorbic acid enhances the cytotoxic effect of 6-hydroxydopamine for human neuroblastoma cell lines

C. Patrick Reynolds; J. Regino Perez-Polo

doi:10.1016/0304-3940(81)90341-4

Ascorbic acid enhances the cytotoxic effect of 6-hydroxydopamine for human neuroblastoma cell lines

C. Patrick Reynolds
, J. Regino Perez-Polo

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Determination of LD₅₀ values showed 3 human neuroblastoma cell lines to be 2-8-fold more sensitive to 6-hydroxydopamine (6-OHDA) than a mouse sarcoma cell line. Treatment of the cells with 6-OHDA and ascorbic acid decreased the cytotoxicity of 6-OHDA for the sarcoma cells and increased cytotoxicity for the 3 neuroblastoma cell lines.

Original language	English (US)
Pages (from-to)	151-155
Number of pages	5
Journal	Neuroscience Letters
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(81)90341-4
State	Published - Oct 23 1981
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(81)90341-4

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title = "Ascorbic acid enhances the cytotoxic effect of 6-hydroxydopamine for human neuroblastoma cell lines",

abstract = "Determination of LD50 values showed 3 human neuroblastoma cell lines to be 2-8-fold more sensitive to 6-hydroxydopamine (6-OHDA) than a mouse sarcoma cell line. Treatment of the cells with 6-OHDA and ascorbic acid decreased the cytotoxicity of 6-OHDA for the sarcoma cells and increased cytotoxicity for the 3 neuroblastoma cell lines.",

author = "Reynolds, \{C. Patrick\} and Perez-Polo, \{J. Regino\}",

note = "Funding Information: Supported by NINCDS Grants NS15324, NS14034, and RCDA NS00213 to J.R.P-P. Thanks to B. Dzambo for manuscript preparation.",

year = "1981",

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doi = "10.1016/0304-3940(81)90341-4",

language = "English (US)",

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journal = "Neuroscience Letters",

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publisher = "Elsevier Ireland Ltd",

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T1 - Ascorbic acid enhances the cytotoxic effect of 6-hydroxydopamine for human neuroblastoma cell lines

AU - Reynolds, C. Patrick

AU - Perez-Polo, J. Regino

N1 - Funding Information: Supported by NINCDS Grants NS15324, NS14034, and RCDA NS00213 to J.R.P-P. Thanks to B. Dzambo for manuscript preparation.

PY - 1981/10/23

Y1 - 1981/10/23

N2 - Determination of LD50 values showed 3 human neuroblastoma cell lines to be 2-8-fold more sensitive to 6-hydroxydopamine (6-OHDA) than a mouse sarcoma cell line. Treatment of the cells with 6-OHDA and ascorbic acid decreased the cytotoxicity of 6-OHDA for the sarcoma cells and increased cytotoxicity for the 3 neuroblastoma cell lines.

AB - Determination of LD50 values showed 3 human neuroblastoma cell lines to be 2-8-fold more sensitive to 6-hydroxydopamine (6-OHDA) than a mouse sarcoma cell line. Treatment of the cells with 6-OHDA and ascorbic acid decreased the cytotoxicity of 6-OHDA for the sarcoma cells and increased cytotoxicity for the 3 neuroblastoma cell lines.

UR - https://www.scopus.com/pages/publications/0019813684

UR - https://www.scopus.com/pages/publications/0019813684#tab=citedBy

U2 - 10.1016/0304-3940(81)90341-4

DO - 10.1016/0304-3940(81)90341-4

M3 - Article

C2 - 6795547

AN - SCOPUS:0019813684

SN - 0304-3940

VL - 26

SP - 151

EP - 155

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Ascorbic acid enhances the cytotoxic effect of 6-hydroxydopamine for human neuroblastoma cell lines

Abstract

ASJC Scopus subject areas

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