Aspartate immunoreactive axons in normal rat L4 dorsal roots

Karin N. Westlund, Daniel L. McNeill, Joel Patterson, Richard E. Coggeshall

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The present study demonstrates that approximately 15% of the unmyelinated axons and 4% of the myelinated axons in the rat L4 dorsal root are immunostained for the excitatory amino acid aspartate. Thus these primary afferent axons contain enough of the antigen to be labeled. This is the first report that high concentrations of aspartate characterize a subpopulation of dorsal root axons. This allows the suggestion that aspartate is a candidate transmitter for primary afferent neurons. We emphasize that these axons are demonstrated in otherwise normal animals so that changes in percentages of labeled axons in response to various stimuli are not complicated by manipulations usually necessary to demonstrate immunoreactive compounds in the cell body.

Original languageEnglish (US)
Pages (from-to)347-351
Number of pages5
JournalBrain Research
Volume489
Issue number2
DOIs
StatePublished - Jun 12 1989

Fingerprint

Spinal Nerve Roots
Aspartic Acid
Axons
Afferent Neurons
Excitatory Amino Acids
Antigens

Keywords

  • Aspartate
  • Immunocytochemistry
  • Primary afferent fiber

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Aspartate immunoreactive axons in normal rat L4 dorsal roots. / Westlund, Karin N.; McNeill, Daniel L.; Patterson, Joel; Coggeshall, Richard E.

In: Brain Research, Vol. 489, No. 2, 12.06.1989, p. 347-351.

Research output: Contribution to journalArticle

Westlund, Karin N. ; McNeill, Daniel L. ; Patterson, Joel ; Coggeshall, Richard E. / Aspartate immunoreactive axons in normal rat L4 dorsal roots. In: Brain Research. 1989 ; Vol. 489, No. 2. pp. 347-351.
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