Aspartoacyclase deficiency and N-acetylaspartic aciduria in patients with Canavan disease

Reuben Matalon, K. Michals, D. Sebesta, M. Deanching, P. Gashkoff, J. Casanova

Research output: Contribution to journalArticle

293 Citations (Scopus)

Abstract

An increased amount of N-acetylaspartic acid was found in urine and plasma of three patients, from two families, with the diagnosis of cerebral spongy degeneration (Canavan disease). Aspartoacyclase was assayed in cultured skin fibroblasts from one patient of each family and a profound deficiency of this enzyme was found. Although the function of N-acetylaspartic acid is not understood, it is known to occur in high concentration in human brain. The finding of a defect in the metabolism of N-acetylaspartic acid causing progressive spongy degeneration of the brain may lead to a better understanding of the function of this amino acid derivative. The aspartoacyclase assay affords a new tool for determining the diagnosis of Canavan disease. Since aspartoacyclase activity was present in cultured amniotic cells and chorionic villi, it is likely that the assay for this enzyme can be used for the prenatal diagnosis of Canavan disease.

Original languageEnglish (US)
Pages (from-to)463-471
Number of pages9
JournalAmerican Journal of Medical Genetics
Volume29
Issue number2
StatePublished - 1988
Externally publishedYes

Fingerprint

Canavan Disease
Chorionic Villi
Enzyme Assays
Prenatal Diagnosis
Cultured Cells
Fibroblasts
Urine
Amino Acids
Skin
Brain
Enzymes
N-acetylaspartate

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Matalon, R., Michals, K., Sebesta, D., Deanching, M., Gashkoff, P., & Casanova, J. (1988). Aspartoacyclase deficiency and N-acetylaspartic aciduria in patients with Canavan disease. American Journal of Medical Genetics, 29(2), 463-471.

Aspartoacyclase deficiency and N-acetylaspartic aciduria in patients with Canavan disease. / Matalon, Reuben; Michals, K.; Sebesta, D.; Deanching, M.; Gashkoff, P.; Casanova, J.

In: American Journal of Medical Genetics, Vol. 29, No. 2, 1988, p. 463-471.

Research output: Contribution to journalArticle

Matalon, R, Michals, K, Sebesta, D, Deanching, M, Gashkoff, P & Casanova, J 1988, 'Aspartoacyclase deficiency and N-acetylaspartic aciduria in patients with Canavan disease', American Journal of Medical Genetics, vol. 29, no. 2, pp. 463-471.
Matalon, Reuben ; Michals, K. ; Sebesta, D. ; Deanching, M. ; Gashkoff, P. ; Casanova, J. / Aspartoacyclase deficiency and N-acetylaspartic aciduria in patients with Canavan disease. In: American Journal of Medical Genetics. 1988 ; Vol. 29, No. 2. pp. 463-471.
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