Aspirin induces hepatoma-derived cell apoptosis via a hydrogen peroxide-dependent pathway

Demidmaa Tuvdendorj, Makoto Oketani, Ryuji Ikeda, Kazunori Kohara, Yasuzi Komorizono, Kazuaki Ishibashi, Namid Munkhtuvshin, Terukatsu Arima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Here we studied whether aspirin (ASA) has any influence on viability of human hepatoma-derived SKHep-1 cells and whether hydrogen peroxide (H2O2) has any relation with this effect. ASA inhibited SKHep-1 cell proliferation dose- and time-dependently. Intracellular H2O2 increased as early as 15 min after ASA supplementation. Cellular apoptosis correlated with an increase in intracellular H2O2 level. Moreover, in the presence of a catalase inhibitor-aminotriazol, ASA showed more apoptotic effect on SKHep-1 cells with increasing intracellular H2O2 level. In conclusion, the present results shows that ASA induced SKHep-1 cell apoptosis has a relation with an early increase in intracellular H2O2 level and catalase inhibitor synergizes to induce this process.

Original languageEnglish (US)
Pages (from-to)47-54
Number of pages8
JournalHepatology Research
Volume26
Issue number1
DOIs
StatePublished - May 1 2003
Externally publishedYes

Fingerprint

Hydrogen Peroxide
Aspirin
Hepatocellular Carcinoma
Apoptosis
Catalase
Cell Proliferation

Keywords

  • Acetylsalicylic acid
  • Aminotriazol
  • Hepatocellular carcinoma
  • Hydrogen peroxide
  • SKHep-1

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Aspirin induces hepatoma-derived cell apoptosis via a hydrogen peroxide-dependent pathway. / Tuvdendorj, Demidmaa; Oketani, Makoto; Ikeda, Ryuji; Kohara, Kazunori; Komorizono, Yasuzi; Ishibashi, Kazuaki; Munkhtuvshin, Namid; Arima, Terukatsu.

In: Hepatology Research, Vol. 26, No. 1, 01.05.2003, p. 47-54.

Research output: Contribution to journalArticle

Tuvdendorj, D, Oketani, M, Ikeda, R, Kohara, K, Komorizono, Y, Ishibashi, K, Munkhtuvshin, N & Arima, T 2003, 'Aspirin induces hepatoma-derived cell apoptosis via a hydrogen peroxide-dependent pathway', Hepatology Research, vol. 26, no. 1, pp. 47-54. https://doi.org/10.1016/S1386-6346(03)00003-2
Tuvdendorj, Demidmaa ; Oketani, Makoto ; Ikeda, Ryuji ; Kohara, Kazunori ; Komorizono, Yasuzi ; Ishibashi, Kazuaki ; Munkhtuvshin, Namid ; Arima, Terukatsu. / Aspirin induces hepatoma-derived cell apoptosis via a hydrogen peroxide-dependent pathway. In: Hepatology Research. 2003 ; Vol. 26, No. 1. pp. 47-54.
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AU - Ikeda, Ryuji

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AU - Komorizono, Yasuzi

AU - Ishibashi, Kazuaki

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