Aspirin induces hepatoma-derived cell apoptosis via a hydrogen peroxide-dependent pathway

Demidmaa Tuvdendorj, Makoto Oketani, Ryuji Ikeda, Kazunori Kohara, Yasuzi Komorizono, Kazuaki Ishibashi, Namid Munkhtuvshin, Terukatsu Arima

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5 Scopus citations

Abstract

Here we studied whether aspirin (ASA) has any influence on viability of human hepatoma-derived SKHep-1 cells and whether hydrogen peroxide (H2O2) has any relation with this effect. ASA inhibited SKHep-1 cell proliferation dose- and time-dependently. Intracellular H2O2 increased as early as 15 min after ASA supplementation. Cellular apoptosis correlated with an increase in intracellular H2O2 level. Moreover, in the presence of a catalase inhibitor-aminotriazol, ASA showed more apoptotic effect on SKHep-1 cells with increasing intracellular H2O2 level. In conclusion, the present results shows that ASA induced SKHep-1 cell apoptosis has a relation with an early increase in intracellular H2O2 level and catalase inhibitor synergizes to induce this process.

Original languageEnglish (US)
Pages (from-to)47-54
Number of pages8
JournalHepatology Research
Volume26
Issue number1
DOIs
StatePublished - May 1 2003
Externally publishedYes

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Keywords

  • Acetylsalicylic acid
  • Aminotriazol
  • Hepatocellular carcinoma
  • Hydrogen peroxide
  • SKHep-1

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases

Cite this

Tuvdendorj, D., Oketani, M., Ikeda, R., Kohara, K., Komorizono, Y., Ishibashi, K., Munkhtuvshin, N., & Arima, T. (2003). Aspirin induces hepatoma-derived cell apoptosis via a hydrogen peroxide-dependent pathway. Hepatology Research, 26(1), 47-54. https://doi.org/10.1016/S1386-6346(03)00003-2