Assessing vessel damage with color Doppler optical coherence tomography following irradiations with cooling

Gracie Vargas, Jennifer Kehlet Barton, Bernard Choi, Joseph A. Izatt, Ashley J. Welch

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The effects of cooling, laser irradiation, and laser irradiation with cooling on blood vessels were investigated with Color Doppler Optical Coherence Tomography (CDOCT). CDOCT may contribute to an understanding of the dynamics of laser-blood vessel interactions and aid in better optimization of laser parameters to be used. In this study, hamster dorsal skin flap window vessels were irradiated with a KTP laser operating at 532 nm. Irradiation sites were imaged with CDOCT prior to, during, immediately after, and several days after irradiation. KTP laser parameters were: radiant exposures in the range of 7-14 J/cm 2, 3 mm spot size, and 10 ms pulse duration. Magnitude and color Doppler images provided information such as vessel size, depth, and changes in blood flow velocity. Vessel constriction, temporary occlusion, and changes in flow were frequent results of laser irradiation visualized with CDOCT. In addition, the effects of cooling alone were imaged with CDOCT and its effects on blood vessel flow and morphology were investigated before and after laser irradiation.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages185-194
Number of pages10
Volume3598
StatePublished - 1999
Externally publishedYes
EventProceedings of the 1999 Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III - San Jose, CA, USA
Duration: Jan 27 1999Jan 29 1999

Other

OtherProceedings of the 1999 Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III
CitySan Jose, CA, USA
Period1/27/991/29/99

Fingerprint

Optical tomography
vessels
tomography
Irradiation
Laser beam effects
damage
Cooling
Color
color
cooling
irradiation
Blood vessels
blood vessels
lasers
Lasers
laser cooling
hamsters
occlusion
Flow velocity
blood flow

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Vargas, G., Barton, J. K., Choi, B., Izatt, J. A., & Welch, A. J. (1999). Assessing vessel damage with color Doppler optical coherence tomography following irradiations with cooling. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3598, pp. 185-194). Society of Photo-Optical Instrumentation Engineers.

Assessing vessel damage with color Doppler optical coherence tomography following irradiations with cooling. / Vargas, Gracie; Barton, Jennifer Kehlet; Choi, Bernard; Izatt, Joseph A.; Welch, Ashley J.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3598 Society of Photo-Optical Instrumentation Engineers, 1999. p. 185-194.

Research output: Chapter in Book/Report/Conference proceedingChapter

Vargas, G, Barton, JK, Choi, B, Izatt, JA & Welch, AJ 1999, Assessing vessel damage with color Doppler optical coherence tomography following irradiations with cooling. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 3598, Society of Photo-Optical Instrumentation Engineers, pp. 185-194, Proceedings of the 1999 Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III, San Jose, CA, USA, 1/27/99.
Vargas G, Barton JK, Choi B, Izatt JA, Welch AJ. Assessing vessel damage with color Doppler optical coherence tomography following irradiations with cooling. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3598. Society of Photo-Optical Instrumentation Engineers. 1999. p. 185-194
Vargas, Gracie ; Barton, Jennifer Kehlet ; Choi, Bernard ; Izatt, Joseph A. ; Welch, Ashley J. / Assessing vessel damage with color Doppler optical coherence tomography following irradiations with cooling. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3598 Society of Photo-Optical Instrumentation Engineers, 1999. pp. 185-194
@inbook{8f6e2182539a476f8e2fbce19a31c008,
title = "Assessing vessel damage with color Doppler optical coherence tomography following irradiations with cooling",
abstract = "The effects of cooling, laser irradiation, and laser irradiation with cooling on blood vessels were investigated with Color Doppler Optical Coherence Tomography (CDOCT). CDOCT may contribute to an understanding of the dynamics of laser-blood vessel interactions and aid in better optimization of laser parameters to be used. In this study, hamster dorsal skin flap window vessels were irradiated with a KTP laser operating at 532 nm. Irradiation sites were imaged with CDOCT prior to, during, immediately after, and several days after irradiation. KTP laser parameters were: radiant exposures in the range of 7-14 J/cm 2, 3 mm spot size, and 10 ms pulse duration. Magnitude and color Doppler images provided information such as vessel size, depth, and changes in blood flow velocity. Vessel constriction, temporary occlusion, and changes in flow were frequent results of laser irradiation visualized with CDOCT. In addition, the effects of cooling alone were imaged with CDOCT and its effects on blood vessel flow and morphology were investigated before and after laser irradiation.",
author = "Gracie Vargas and Barton, {Jennifer Kehlet} and Bernard Choi and Izatt, {Joseph A.} and Welch, {Ashley J.}",
year = "1999",
language = "English (US)",
volume = "3598",
pages = "185--194",
booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "Society of Photo-Optical Instrumentation Engineers",

}

TY - CHAP

T1 - Assessing vessel damage with color Doppler optical coherence tomography following irradiations with cooling

AU - Vargas, Gracie

AU - Barton, Jennifer Kehlet

AU - Choi, Bernard

AU - Izatt, Joseph A.

AU - Welch, Ashley J.

PY - 1999

Y1 - 1999

N2 - The effects of cooling, laser irradiation, and laser irradiation with cooling on blood vessels were investigated with Color Doppler Optical Coherence Tomography (CDOCT). CDOCT may contribute to an understanding of the dynamics of laser-blood vessel interactions and aid in better optimization of laser parameters to be used. In this study, hamster dorsal skin flap window vessels were irradiated with a KTP laser operating at 532 nm. Irradiation sites were imaged with CDOCT prior to, during, immediately after, and several days after irradiation. KTP laser parameters were: radiant exposures in the range of 7-14 J/cm 2, 3 mm spot size, and 10 ms pulse duration. Magnitude and color Doppler images provided information such as vessel size, depth, and changes in blood flow velocity. Vessel constriction, temporary occlusion, and changes in flow were frequent results of laser irradiation visualized with CDOCT. In addition, the effects of cooling alone were imaged with CDOCT and its effects on blood vessel flow and morphology were investigated before and after laser irradiation.

AB - The effects of cooling, laser irradiation, and laser irradiation with cooling on blood vessels were investigated with Color Doppler Optical Coherence Tomography (CDOCT). CDOCT may contribute to an understanding of the dynamics of laser-blood vessel interactions and aid in better optimization of laser parameters to be used. In this study, hamster dorsal skin flap window vessels were irradiated with a KTP laser operating at 532 nm. Irradiation sites were imaged with CDOCT prior to, during, immediately after, and several days after irradiation. KTP laser parameters were: radiant exposures in the range of 7-14 J/cm 2, 3 mm spot size, and 10 ms pulse duration. Magnitude and color Doppler images provided information such as vessel size, depth, and changes in blood flow velocity. Vessel constriction, temporary occlusion, and changes in flow were frequent results of laser irradiation visualized with CDOCT. In addition, the effects of cooling alone were imaged with CDOCT and its effects on blood vessel flow and morphology were investigated before and after laser irradiation.

UR - http://www.scopus.com/inward/record.url?scp=0032634080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032634080&partnerID=8YFLogxK

M3 - Chapter

VL - 3598

SP - 185

EP - 194

BT - Proceedings of SPIE - The International Society for Optical Engineering

PB - Society of Photo-Optical Instrumentation Engineers

ER -