Assessment of lung inflammation with 18F-FDG PET during acute lung injury

Nicolas De Prost, Mauro R. Tucci, Marcos F. Vidal Melo

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations

Abstract

OBJECTIVE. The purpose of this review is to describe the current experimental and clinical data regarding the fundamentals and applications of 18F-FDG PET during acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). CONCLUSION. Lung inflammation is a key feature of ALI. During ALI, FDG PET can be used to monitor lung neutrophils, which are essential cells in the pathophysiologic mechanisms of ALI. Pulmonary FDG kinetics are altered during experimental and human ALI and are associated with regional lung dysfunction, histologic abnormalities, and prognosis. FDG PET may be a valuable noninvasive method for gaining comprehensive understanding of the mechanisms of ALI/ARDS and for evaluating therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)292-300
Number of pages9
JournalAmerican Journal of Roentgenology
Volume195
Issue number2
DOIs
StatePublished - Aug 2010
Externally publishedYes

Keywords

  • F-FDG
  • Acute lung injury
  • Acute respiratory distress syndrome
  • Adults
  • PET

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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