Assessment of methylsulfonylmethane as a permeability enhancer for regional EDTA chelation therapy Methylsulfonylmethane as a permeability enhancer Min Zhang et al.

Min Zhang, Ira G. Wong, Jerry B. Gin, Naseem Ansari

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Pharmacologic chelators do not effectively penetrate cell membranes and bloodbrain barrier. This study assesses methylsulfonylmethane (MSM) as a permeability enhancer and an excipient to facilitate EDTA transport across biologic membranes, and to make possible localized, regional chelation. Topical application of MSM with C14EDTA onto the rat cornea led to uptake of the C14EDTA in all tested ocular tissues. Without MSM, EDTA did not penetrate the eye. The ability of MSM to deliver EDTA into an eye provides an opportunity for regional chelation therapy. Additionally, these studies suggest that MSM could also be an adjuvant for delivering ciprofloxacin and other chemical compounds to specific, local tissue sites.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalDrug Delivery
Volume16
Issue number5
DOIs
StatePublished - 2009

Fingerprint

Chelation Therapy
Edetic Acid
Permeability
Biological Transport
Excipients
Ciprofloxacin
Chelating Agents
Cornea
Cell Membrane
Membranes
dimethyl sulfone

Keywords

  • Chelation therapy
  • Ciprofloxacin
  • Ethylenediaminetetraacetic acid (EDTA)
  • Metal chelation
  • Methylsulfonylmethane (MSM)
  • Permeability enhancers

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Assessment of methylsulfonylmethane as a permeability enhancer for regional EDTA chelation therapy Methylsulfonylmethane as a permeability enhancer Min Zhang et al. / Zhang, Min; Wong, Ira G.; Gin, Jerry B.; Ansari, Naseem.

In: Drug Delivery, Vol. 16, No. 5, 2009, p. 243-248.

Research output: Contribution to journalArticle

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