Assessment of methylsulfonylmethane as a permeability enhancer for regional EDTA chelation therapy Methylsulfonylmethane as a permeability enhancer Min Zhang et al.

Min Zhang, Ira G. Wong, Jerry B. Gin, Naseem H. Ansari

Research output: Contribution to journalArticle

16 Scopus citations


Pharmacologic chelators do not effectively penetrate cell membranes and bloodbrain barrier. This study assesses methylsulfonylmethane (MSM) as a permeability enhancer and an excipient to facilitate EDTA transport across biologic membranes, and to make possible localized, regional chelation. Topical application of MSM with C14EDTA onto the rat cornea led to uptake of the C14EDTA in all tested ocular tissues. Without MSM, EDTA did not penetrate the eye. The ability of MSM to deliver EDTA into an eye provides an opportunity for regional chelation therapy. Additionally, these studies suggest that MSM could also be an adjuvant for delivering ciprofloxacin and other chemical compounds to specific, local tissue sites.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalDrug Delivery
Issue number5
StatePublished - Nov 9 2009



  • Chelation therapy
  • Ciprofloxacin
  • Ethylenediaminetetraacetic acid (EDTA)
  • Metal chelation
  • Methylsulfonylmethane (MSM)
  • Permeability enhancers

ASJC Scopus subject areas

  • Pharmaceutical Science

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