Assisted reproductive technology and pregnancy outcome

Tracy Shevell, Fergal D. Malone, John Vidaver, T. Flint Porter, David A. Luthy, Christine H. Comstock, Gary Hankins, Keith Eddleman, Siobhan Dolan, Lorraine Dugoff, Sabrina Craigo, Ilan E. Timor, Stephen R. Carr, Honor M. Wolfe, Diana W. Bianchi, Mary E. D'Alton

Research output: Contribution to journalArticle

222 Citations (Scopus)

Abstract

OBJECTIVE: To determine whether the use of assisted reproductive technology (ART) is associated with an increase in chromosomal abnormalities, fetal malformations, or adverse pregnancy outcomes. METHODS: A prospective database from a large multicenter investigation of singleton pregnancies, the First And Second Trimester Evaluation of Risk trial, was examined. Subjects were divided into 3 groups: no ART use, use of ovulation induction (with or without intrauterine insemination), and use of in vitro fertilization (IVF). Multivariate logistic regression analysis was used to assess association between ART and adverse pregnancy outcomes (significance of differences was accepted at P < .05). RESULTS: A total of 36,062 pregnancies were analyzed: 34,286 (95.1%) were spontaneously conceived, 1,222 (3.4%) used ovulation induction, and 554 (1.5%) used IVF. There was no association between ART and fetal growth restriction, aneuploidy, or fetal anomalies after adjustment for age, race, marital status, years of education, prior preterm delivery, prior fetal anomaly, body mass index, smoking history, and bleeding in the current pregnancy. Ovulation induction was associated with a statistically significant increase in placental abruption, fetal loss after 24 weeks, and gestational diabetes after adjustment. Use of IVF was associated with a statistically significant increase in preeclampsia, gestational hypertension, placental abruption, placenta previa, and risk of cesarean delivery. CONCLUSION: Patients who undergo IVF are at increased risk for several adverse pregnancy outcomes. Although many of these risks are not seen in patients undergoing ovulation induction, several adverse pregnancy outcomes are still increased in this group. There was no increased incidence of fetal chromosomal or structural abnormalities in the women who used any type of ART compared with the women who conceived spontaneously.

Original languageEnglish (US)
Pages (from-to)1039-1045
Number of pages7
JournalObstetrics and Gynecology
Volume106
Issue number5 I
StatePublished - Nov 2005
Externally publishedYes

Fingerprint

Assisted Reproductive Techniques
Pregnancy Outcome
Ovulation Induction
Fertilization in Vitro
Abruptio Placentae
Placenta Previa
Social Adjustment
Pregnancy
Pregnancy Induced Hypertension
Gestational Diabetes
Insemination
Marital Status
Second Pregnancy Trimester
Aneuploidy
First Pregnancy Trimester
Fetal Development
Pre-Eclampsia
Chromosome Aberrations
Body Mass Index
Logistic Models

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Shevell, T., Malone, F. D., Vidaver, J., Porter, T. F., Luthy, D. A., Comstock, C. H., ... D'Alton, M. E. (2005). Assisted reproductive technology and pregnancy outcome. Obstetrics and Gynecology, 106(5 I), 1039-1045.

Assisted reproductive technology and pregnancy outcome. / Shevell, Tracy; Malone, Fergal D.; Vidaver, John; Porter, T. Flint; Luthy, David A.; Comstock, Christine H.; Hankins, Gary; Eddleman, Keith; Dolan, Siobhan; Dugoff, Lorraine; Craigo, Sabrina; Timor, Ilan E.; Carr, Stephen R.; Wolfe, Honor M.; Bianchi, Diana W.; D'Alton, Mary E.

In: Obstetrics and Gynecology, Vol. 106, No. 5 I, 11.2005, p. 1039-1045.

Research output: Contribution to journalArticle

Shevell, T, Malone, FD, Vidaver, J, Porter, TF, Luthy, DA, Comstock, CH, Hankins, G, Eddleman, K, Dolan, S, Dugoff, L, Craigo, S, Timor, IE, Carr, SR, Wolfe, HM, Bianchi, DW & D'Alton, ME 2005, 'Assisted reproductive technology and pregnancy outcome', Obstetrics and Gynecology, vol. 106, no. 5 I, pp. 1039-1045.
Shevell T, Malone FD, Vidaver J, Porter TF, Luthy DA, Comstock CH et al. Assisted reproductive technology and pregnancy outcome. Obstetrics and Gynecology. 2005 Nov;106(5 I):1039-1045.
Shevell, Tracy ; Malone, Fergal D. ; Vidaver, John ; Porter, T. Flint ; Luthy, David A. ; Comstock, Christine H. ; Hankins, Gary ; Eddleman, Keith ; Dolan, Siobhan ; Dugoff, Lorraine ; Craigo, Sabrina ; Timor, Ilan E. ; Carr, Stephen R. ; Wolfe, Honor M. ; Bianchi, Diana W. ; D'Alton, Mary E. / Assisted reproductive technology and pregnancy outcome. In: Obstetrics and Gynecology. 2005 ; Vol. 106, No. 5 I. pp. 1039-1045.
@article{cab21033abbc4e5795f1ef7db08eb8be,
title = "Assisted reproductive technology and pregnancy outcome",
abstract = "OBJECTIVE: To determine whether the use of assisted reproductive technology (ART) is associated with an increase in chromosomal abnormalities, fetal malformations, or adverse pregnancy outcomes. METHODS: A prospective database from a large multicenter investigation of singleton pregnancies, the First And Second Trimester Evaluation of Risk trial, was examined. Subjects were divided into 3 groups: no ART use, use of ovulation induction (with or without intrauterine insemination), and use of in vitro fertilization (IVF). Multivariate logistic regression analysis was used to assess association between ART and adverse pregnancy outcomes (significance of differences was accepted at P < .05). RESULTS: A total of 36,062 pregnancies were analyzed: 34,286 (95.1{\%}) were spontaneously conceived, 1,222 (3.4{\%}) used ovulation induction, and 554 (1.5{\%}) used IVF. There was no association between ART and fetal growth restriction, aneuploidy, or fetal anomalies after adjustment for age, race, marital status, years of education, prior preterm delivery, prior fetal anomaly, body mass index, smoking history, and bleeding in the current pregnancy. Ovulation induction was associated with a statistically significant increase in placental abruption, fetal loss after 24 weeks, and gestational diabetes after adjustment. Use of IVF was associated with a statistically significant increase in preeclampsia, gestational hypertension, placental abruption, placenta previa, and risk of cesarean delivery. CONCLUSION: Patients who undergo IVF are at increased risk for several adverse pregnancy outcomes. Although many of these risks are not seen in patients undergoing ovulation induction, several adverse pregnancy outcomes are still increased in this group. There was no increased incidence of fetal chromosomal or structural abnormalities in the women who used any type of ART compared with the women who conceived spontaneously.",
author = "Tracy Shevell and Malone, {Fergal D.} and John Vidaver and Porter, {T. Flint} and Luthy, {David A.} and Comstock, {Christine H.} and Gary Hankins and Keith Eddleman and Siobhan Dolan and Lorraine Dugoff and Sabrina Craigo and Timor, {Ilan E.} and Carr, {Stephen R.} and Wolfe, {Honor M.} and Bianchi, {Diana W.} and D'Alton, {Mary E.}",
year = "2005",
month = "11",
language = "English (US)",
volume = "106",
pages = "1039--1045",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "5 I",

}

TY - JOUR

T1 - Assisted reproductive technology and pregnancy outcome

AU - Shevell, Tracy

AU - Malone, Fergal D.

AU - Vidaver, John

AU - Porter, T. Flint

AU - Luthy, David A.

AU - Comstock, Christine H.

AU - Hankins, Gary

AU - Eddleman, Keith

AU - Dolan, Siobhan

AU - Dugoff, Lorraine

AU - Craigo, Sabrina

AU - Timor, Ilan E.

AU - Carr, Stephen R.

AU - Wolfe, Honor M.

AU - Bianchi, Diana W.

AU - D'Alton, Mary E.

PY - 2005/11

Y1 - 2005/11

N2 - OBJECTIVE: To determine whether the use of assisted reproductive technology (ART) is associated with an increase in chromosomal abnormalities, fetal malformations, or adverse pregnancy outcomes. METHODS: A prospective database from a large multicenter investigation of singleton pregnancies, the First And Second Trimester Evaluation of Risk trial, was examined. Subjects were divided into 3 groups: no ART use, use of ovulation induction (with or without intrauterine insemination), and use of in vitro fertilization (IVF). Multivariate logistic regression analysis was used to assess association between ART and adverse pregnancy outcomes (significance of differences was accepted at P < .05). RESULTS: A total of 36,062 pregnancies were analyzed: 34,286 (95.1%) were spontaneously conceived, 1,222 (3.4%) used ovulation induction, and 554 (1.5%) used IVF. There was no association between ART and fetal growth restriction, aneuploidy, or fetal anomalies after adjustment for age, race, marital status, years of education, prior preterm delivery, prior fetal anomaly, body mass index, smoking history, and bleeding in the current pregnancy. Ovulation induction was associated with a statistically significant increase in placental abruption, fetal loss after 24 weeks, and gestational diabetes after adjustment. Use of IVF was associated with a statistically significant increase in preeclampsia, gestational hypertension, placental abruption, placenta previa, and risk of cesarean delivery. CONCLUSION: Patients who undergo IVF are at increased risk for several adverse pregnancy outcomes. Although many of these risks are not seen in patients undergoing ovulation induction, several adverse pregnancy outcomes are still increased in this group. There was no increased incidence of fetal chromosomal or structural abnormalities in the women who used any type of ART compared with the women who conceived spontaneously.

AB - OBJECTIVE: To determine whether the use of assisted reproductive technology (ART) is associated with an increase in chromosomal abnormalities, fetal malformations, or adverse pregnancy outcomes. METHODS: A prospective database from a large multicenter investigation of singleton pregnancies, the First And Second Trimester Evaluation of Risk trial, was examined. Subjects were divided into 3 groups: no ART use, use of ovulation induction (with or without intrauterine insemination), and use of in vitro fertilization (IVF). Multivariate logistic regression analysis was used to assess association between ART and adverse pregnancy outcomes (significance of differences was accepted at P < .05). RESULTS: A total of 36,062 pregnancies were analyzed: 34,286 (95.1%) were spontaneously conceived, 1,222 (3.4%) used ovulation induction, and 554 (1.5%) used IVF. There was no association between ART and fetal growth restriction, aneuploidy, or fetal anomalies after adjustment for age, race, marital status, years of education, prior preterm delivery, prior fetal anomaly, body mass index, smoking history, and bleeding in the current pregnancy. Ovulation induction was associated with a statistically significant increase in placental abruption, fetal loss after 24 weeks, and gestational diabetes after adjustment. Use of IVF was associated with a statistically significant increase in preeclampsia, gestational hypertension, placental abruption, placenta previa, and risk of cesarean delivery. CONCLUSION: Patients who undergo IVF are at increased risk for several adverse pregnancy outcomes. Although many of these risks are not seen in patients undergoing ovulation induction, several adverse pregnancy outcomes are still increased in this group. There was no increased incidence of fetal chromosomal or structural abnormalities in the women who used any type of ART compared with the women who conceived spontaneously.

UR - http://www.scopus.com/inward/record.url?scp=27444439562&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27444439562&partnerID=8YFLogxK

M3 - Article

C2 - 16260523

AN - SCOPUS:27444439562

VL - 106

SP - 1039

EP - 1045

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 5 I

ER -