Association between blood pressure and risk of cancer development

a systematic review and meta-analysis of observational studies

Aristeidis Seretis, Sofia Cividini, Georgios Markozannes, Xanthippi Tseretopoulou, David Lopez, Evangelia E. Ntzani, Konstantinos K. Tsilidis

Research output: Contribution to journalArticle

Abstract

With the exception of renal cell carcinoma, studies assessing the association between hypertension and other cancers are inconsistent. We conducted a meta-analysis to assess this evidence. We included observational studies investigating the association between any definition of hypertension or systolic and diastolic blood pressure and risk of any cancer, after searching PubMed until November 2017. We calculated summary relative risks (RR) and 95% confidence intervals (CI) using inverse-variance weighted random effects methods. A total of 148 eligible publications were identified out of 39,891 initially screened citations. Considering only evidence from 85 prospective studies, positive associations were observed between hypertension and kidney, colorectal and breast cancer. Positive associations between hypertension and risk of oesophageal adenocarcinoma and squamous cell carcinoma, liver and endometrial cancer were also observed, but the majority of studies did not perform comprehensive multivariable adjustments. Systolic and diastolic blood pressure were positively associated with risk of kidney cancer but not with other cancers. In addition to the previously well-described association between hypertension and risk of kidney cancer, the current meta-analysis suggested that hypertensive individuals may also be at higher risk of colorectal and breast cancer. However, careful interpretation is required as most meta-analyses included relatively small number of studies, several relative risks had weak or moderate magnitude and maybe affected by residual confounding.

Original languageEnglish (US)
Article number8565
JournalScientific reports
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2019
Externally publishedYes

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Observational Studies
Meta-Analysis
Blood Pressure
Kidney Neoplasms
Hypertension
Neoplasms
Colorectal Neoplasms
Breast Neoplasms
Squamous Cell Neoplasms
Liver Neoplasms
Endometrial Neoplasms
Renal Cell Carcinoma
PubMed
Publications
Adenocarcinoma
Prospective Studies
Confidence Intervals

ASJC Scopus subject areas

  • General

Cite this

Association between blood pressure and risk of cancer development : a systematic review and meta-analysis of observational studies. / Seretis, Aristeidis; Cividini, Sofia; Markozannes, Georgios; Tseretopoulou, Xanthippi; Lopez, David; Ntzani, Evangelia E.; Tsilidis, Konstantinos K.

In: Scientific reports, Vol. 9, No. 1, 8565, 01.12.2019.

Research output: Contribution to journalArticle

Seretis, Aristeidis ; Cividini, Sofia ; Markozannes, Georgios ; Tseretopoulou, Xanthippi ; Lopez, David ; Ntzani, Evangelia E. ; Tsilidis, Konstantinos K. / Association between blood pressure and risk of cancer development : a systematic review and meta-analysis of observational studies. In: Scientific reports. 2019 ; Vol. 9, No. 1.
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