TY - JOUR
T1 - Association between change in systolic blood pressure and cognitive decline among elderly Mexican Americans
T2 - Data from the hispanic established population for epidemiology study of the elderly
AU - Insel, Kathleen C.
AU - Palmer, Raymond F.
AU - Stroup-Benham, Christine A.
AU - Markides, Kyriakos S.
AU - Espino, David V.
N1 - Funding Information:
Received 4 December 2003; accepted 13 May 2004. This research was supported by National Institute on Aging grant R01-AG-10939. Address correspondence to Kathleen Insel, University of Arizona, College of Nursing, PO Box 210203, Tuscon, AZ, 85721-0203, USA. E-mail: insel@nursing.arizona.edu
PY - 2005/1
Y1 - 2005/1
N2 - The longitudinal association between the rate of change in blood pressure and cognitive decline was examined in an area probability sample from a population-based survey of elderly Mexican Americans, 65 years of age or older obtained in 1993-1994, 1995-1996, 1998-1999, and 2000-2001 (n = 2859). The sample was divided into two groups at baseline: hypertensives had a systolic blood pressure (SBP) ≥ 140 mm Hg, a diastolic blood pressure (DBP) ≥ 90 mm Hg, or indicated a prior diagnosis of hypertension, and the normotensive group. Cognition was indexed by the Mini-Mental State Examination (MMSE). Neither SBP nor DBP at baseline predicted cognitive decline. However, the mean slope for SBP in the normotensive group showed an increase of 4.55 mm Hg (increase from Time 1 to Time 2 was 123 mm Hg to 132 mm Hg) and was significant in a regression model predicting cognitive decline even after adjusting for covariates. These findings suggest an association between increasing SBP and cognitive decline for normotensive elderly in this study population.
AB - The longitudinal association between the rate of change in blood pressure and cognitive decline was examined in an area probability sample from a population-based survey of elderly Mexican Americans, 65 years of age or older obtained in 1993-1994, 1995-1996, 1998-1999, and 2000-2001 (n = 2859). The sample was divided into two groups at baseline: hypertensives had a systolic blood pressure (SBP) ≥ 140 mm Hg, a diastolic blood pressure (DBP) ≥ 90 mm Hg, or indicated a prior diagnosis of hypertension, and the normotensive group. Cognition was indexed by the Mini-Mental State Examination (MMSE). Neither SBP nor DBP at baseline predicted cognitive decline. However, the mean slope for SBP in the normotensive group showed an increase of 4.55 mm Hg (increase from Time 1 to Time 2 was 123 mm Hg to 132 mm Hg) and was significant in a regression model predicting cognitive decline even after adjusting for covariates. These findings suggest an association between increasing SBP and cognitive decline for normotensive elderly in this study population.
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U2 - 10.1080/03610730590882837
DO - 10.1080/03610730590882837
M3 - Article
C2 - 15842072
AN - SCOPUS:11244283689
SN - 0361-073X
VL - 31
SP - 35
EP - 54
JO - Experimental Aging Research
JF - Experimental Aging Research
IS - 1
ER -